The Role of PBR/TSPO in Steroid Biosynthesis Challenged

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2013 Dec 25

PMID 24364584

Citations 11

Authors

Douglas M Stocco

Affiliations

Soon will be listed here.

Citing Articles

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Effects of genetic variants in the TSPO gene on protein structure and stability.

Milenkovic V, Bader S, Sudria-Lopez D, Siebert R, Brandl C, Nothdurfter C PLoS One. 2018; 13(4):e0195627.

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Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.

Wang H, Zhai K, Xue Y, Yang J, Yang Q, Fu Y PLoS One. 2016; 11(12):e0167307.

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Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.

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Evolving understanding of translocator protein 18 kDa (TSPO).

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References

Farese R, Prudente W . On the requirement for protein synthesis during corticotropin-induced stimulation of cholesterol side chain cleavage in rat adrenal mitochondrial and solubilized desmolase preparations. Biochim Biophys Acta. 1977; 496(2):567-70. DOI: 10.1016/0304-4165(77)90339-7. View

Papadopoulos V . Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev. 1993; 14(2):222-40. DOI: 10.1210/edrv-14-2-222. View

Papadopoulos V, Berkovich A, KRUEGER K, Costa E, Guidotti A . Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology. 1991; 129(3):1481-8. DOI: 10.1210/endo-129-3-1481. View

Neess D, Bloksgaard M, Bek S, Marcher A, Elle I, Helledie T . Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning. J Biol Chem. 2010; 286(5):3460-72. PMC: 3030352. DOI: 10.1074/jbc.M110.161109. View

Pedersen R, BROWNIE A . Steroidogenesis-activator polypeptide isolated from a rat Leydig cell tumor. Science. 1987; 236(4798):188-90. DOI: 10.1126/science.3563495. View

Papadopoulos V, Nowzari F, KRUEGER K . Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. Tropic hormone action on steroid biosynthesis is inhibited by flunitrazepam. J Biol Chem. 1991; 266(6):3682-7. View

Simpson E, McCARTHY J, Peterson J . Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450. J Biol Chem. 1978; 253(9):3135-9. View

Mukhin A, Papadopoulos V, Costa E, KRUEGER K . Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci U S A. 1989; 86(24):9813-6. PMC: 298592. DOI: 10.1073/pnas.86.24.9813. View

Boujrad N, Gaillard J, Garnier M, Papadopoulos V . Acute action of choriogonadotropin on Leydig tumor cells: induction of a higher affinity benzodiazepine-binding site related to steroid biosynthesis. Endocrinology. 1994; 135(4):1576-83. DOI: 10.1210/endo.135.4.7925120. View

10.

Paul D, Gallant S, Orme-Johnson W, BROWNIE A . Temperature dependence of cholesterol binding to cytochrome P-450scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide. J Biol Chem. 1976; 251(22):7120-6. View

11.

Liu J, Rone M, Papadopoulos V . Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J Biol Chem. 2006; 281(50):38879-93. DOI: 10.1074/jbc.M608820200. View

12.

Crivello J, Jefcoate C . Mechanisms of corticotropin action in rat adrenal cells. I. The effects of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis. Biochim Biophys Acta. 1978; 542(2):315-29. DOI: 10.1016/0304-4165(78)90027-2. View

13.

Papadopoulos V, Guarneri P, Kreuger K, Guidotti A, Costa E . Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci U S A. 1992; 89(11):5113-7. PMC: 49239. DOI: 10.1073/pnas.89.11.5113. View

14.

Morohaku K, Pelton S, Daugherty D, Butler W, Deng W, Selvaraj V . Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology. 2013; 155(1):89-97. PMC: 3868810. DOI: 10.1210/en.2013-1556. View

15.

Farese R . INHIBITION OF THE STEROIDOGENIC EFFECT OF ACTH AND INCORPORATION OF AMINO ACID INTO RAT ADRENAL PROTEIN IN VITRO BY CHLORAMPHENICOL. Biochim Biophys Acta. 1964; 87:699-701. DOI: 10.1016/0926-6550(64)90292-0. View

16.

Papadopoulos V, Baraldi M, Guilarte T, Knudsen T, Lacapere J, Lindemann P . Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006; 27(8):402-9. DOI: 10.1016/j.tips.2006.06.005. View

17.

Papadopoulos V, Brown A . Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. J Steroid Biochem Mol Biol. 1995; 53(1-6):103-10. DOI: 10.1016/0960-0760(95)00027-w. View

18.

Papadopoulos V, Amri H, Li H, Boujrad N, Vidic B, Garnier M . Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem. 1998; 272(51):32129-35. DOI: 10.1074/jbc.272.51.32129. View

19.

Janszen F, COOKE B, VAN DER MOLEN H . Specific protein synthesis in isolated rat testis leydig cells. Influence of luteinizing hormone and cycloheximide. Biochem J. 1977; 162(2):341-6. PMC: 1164606. DOI: 10.1042/bj1620341. View

20.

GARREN L, Gill G, Masui H, Walton G . On the mechanism of action of ACTH. Recent Prog Horm Res. 1971; 27:433-78. DOI: 10.1016/b978-0-12-571127-2.50035-3. View