Novel Insights on Interactions Between Folate and Lipid Metabolism

Overview

Journal Biofactors

Publisher IOS Press

Specialty Biochemistry

Date 2013 Dec 20

PMID 24353111

Citations 71

Authors

Robin P da Silva

Karen B Kelly

Ala Al Rajabi

Rene L Jacobs

Affiliations

Soon will be listed here.

Abstract

Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation reactions that are used for post-translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non-alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid-related folate research.

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