Prognostic Factors Associated with Locally Recurrent Rectal Cancer Following Primary Surgery (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2013 Dec 19

PMID 24348812

Citations 16

Authors

Yantao Cai

Zhenyang Li

Xiaodong Gu

Yantian Fang

Jianbin Xiang

Zongyou Chen

Affiliations

Soon will be listed here.

Abstract

Locally recurrent rectal cancer (LRRC) is defined as an intrapelvic recurrence following a primary rectal cancer resection, with or without distal metastasis. The treatment of LRRC remains a clinical challenge. LRRC has been regarded as an incurable disease state leading to a poor quality of life and a limited survival time. However, curative reoperations have proved beneficial for treating LRRC. A complete resection of recurrent tumors (R0 resection) allows the treatment to be curative rather than palliative, which is a milestone in medicine. In LRRC cases, the difficulty of achieving an R0 resection is associated with the post-operative prognosis and is affected by several clinical factors, including the staging of the local recurrence (LR), accompanying symptoms, patterns of tumors and combined therapy. The risk factors following primary surgery that lead to an increased rate of LR are summarized in this study, including the surgical, pathological and therapeutic factors.

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