Human Papillomavirus Oncoproteins and Apoptosis (Review)

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2013 Dec 19

PMID 24348754

Citations 16

Authors

Peiyue Jiang

Ying Yue

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV-associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor-associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.

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