The Long-term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People After Influenza Vaccination

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2013 Dec 19

PMID 24348705

Citations 11

Authors

Ikuo Saiki

Keiichi Koizumi

Hirozo Goto

Akiko Inujima

Takao Namiki

Masaki Raimura

Toshiaki Kogure

Takeshi Tatsumi

Hiroki Inoue

Shinya Sakai

Hiroshi Oka

Makoto Fujimoto

Hiroaki Hikiami

Hiroaki Sakurai

Naotoshi Shibahara

Yutaka Shimada

Hideki Origasa

Affiliations

Soon will be listed here.

Abstract

We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.

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