Whole-brain Three-dimensional T2-weighted BOLD Functional Magnetic Resonance Imaging at 7 Tesla

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2013 Dec 17

PMID 24338901

Citations 24

Authors

Jun Hua

Qin Qin

Peter C M van Zijl

James J Pekar

Craig K Jones

Affiliations

Soon will be listed here.

Abstract

Purpose: A new acquisition scheme for T2-weighted spin-echo BOLD fMRI is introduced.

Methods: It uses a T2-preparation module to induce blood-oxygenation-level-dependent (BOLD) contrast, followed by a single-shot three-dimensional (3D) fast gradient-echo readout with short echo time (TE). It differs from most spin-echo BOLD sequences in that BOLD contrast is generated before the readout, which eliminates the "dead time" due to long TE required for T2 contrast, and substantially improves acquisition efficiency. This approach, termed "3D T2prep-GRE," was implemented at 7 Tesla (T) with a typical spatial (2.5 × 2.5 × 2.5 mm(3) ) and temporal (TR = 2.3 s) resolution for functional MRI (fMRI) and whole-brain coverage (55 slices), and compared with the widely used 2D spin-echo EPI sequence.

Results: In fMRI experiments of simultaneous visual/motor activities, 3D T2prep-GRE showed minimal distortion and little signal dropout across the whole brain. Its lower power deposition allowed greater spatial coverage (55 versus 17 slices with identical TR, resolution and power level), temporal SNR (60% higher) and CNR (35% higher) efficiency than 2D spin-echo EPI. It also showed smaller T2* contamination.

Conclusion: This approach is expected to be useful for ultra-high field fMRI, especially for regions near air cavities. The concept of using T2-preparation to generate BOLD contrast can be combined with many other sequences at any field strength.

Citing Articles

Differential functional change in olfactory bulb and olfactory eloquent areas in Parkinson's disease.

Luo Y, Miao X, Rajan S, Paez A, Zhou X, Rosenthal L Brain Commun. 2024; 6(6):fcae413.

PMID: 39600523 PMC: 11589462. DOI: 10.1093/braincomms/fcae413.

Whole-cerebrum guanidino and amide CEST mapping at 3 T by a 3D stack-of-spirals gradient echo acquisition.

Wang K, Ju L, Song Y, Blair L, Xie K, Liu C Magn Reson Med. 2024; 92(4):1456-1470.

PMID: 38748853 PMC: 11262991. DOI: 10.1002/mrm.30134.

Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.

Zhang K, Chen L, Li Y, Paez A, Miao X, Cao D J Neurosci. 2023; 43(16):2874-2884.

PMID: 36948584 PMC: 10124959. DOI: 10.1523/JNEUROSCI.1488-22.2023.

Evaluation of T2-prepared blood oxygenation level dependent functional magnetic resonance imaging with an event-related task: Hemodynamic response function and reproducibility.

Miao X, Li Y, Zhou X, Luo Y, Paez A, Liu D Front Neurosci. 2023; 17:1114045.

PMID: 36937683 PMC: 10017524. DOI: 10.3389/fnins.2023.1114045.

A revisit of the k-space filtering effects of magnetization-prepared 3D FLASH and balanced SSFP acquisitions: Analytical characterization of the point spread functions.

Zhu D, Qin Q Magn Reson Imaging. 2022; 88:76-88.

PMID: 35121068 PMC: 8935658. DOI: 10.1016/j.mri.2022.01.015.

References

Schar M, Kozerke S, Fischer S, Boesiger P . Cardiac SSFP imaging at 3 Tesla. Magn Reson Med. 2004; 51(4):799-806. DOI: 10.1002/mrm.20024. View

Nguyen T, Wisnieff C, Cooper M, Kumar D, Raj A, Spincemaille P . T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla. Magn Reson Med. 2012; 67(3):614-21. DOI: 10.1002/mrm.24128. View

EPSTEIN F, Mugler 3rd J, Brookeman J . Optimization of parameter values for complex pulse sequences by simulated annealing: application to 3D MP-RAGE imaging of the brain. Magn Reson Med. 1994; 31(2):164-77. DOI: 10.1002/mrm.1910310210. View

Fujita N . Extravascular contribution of blood oxygenation level-dependent signal changes: a numerical analysis based on a vascular network model. Magn Reson Med. 2001; 46(4):723-34. DOI: 10.1002/mrm.1251. View

Kruger G, Glover G . Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med. 2001; 46(4):631-7. DOI: 10.1002/mrm.1240. View

Haase A . Snapshot FLASH MRI. Applications to T1, T2, and chemical-shift imaging. Magn Reson Med. 1990; 13(1):77-89. DOI: 10.1002/mrm.1910130109. View

Duong T, Yacoub E, Adriany G, Hu X, Ugurbil K, Thomas Vaughan J . High-resolution, spin-echo BOLD, and CBF fMRI at 4 and 7 T. Magn Reson Med. 2002; 48(4):589-93. DOI: 10.1002/mrm.10252. View

Olman C, Harel N, Feinberg D, He S, Zhang P, Ugurbil K . Layer-specific fMRI reflects different neuronal computations at different depths in human V1. PLoS One. 2012; 7(3):e32536. PMC: 3308958. DOI: 10.1371/journal.pone.0032536. View

Wang J, Yarnykh V, Yuan C . Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence. J Magn Reson Imaging. 2010; 31(5):1256-63. PMC: 2908521. DOI: 10.1002/jmri.22149. View

10.

Lu H, Clingman C, Golay X, van Zijl P . Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med. 2004; 52(3):679-82. DOI: 10.1002/mrm.20178. View

11.

Mugler 3rd J, Spraggins T, Brookeman J . T2-weighted three-dimensional MP-RAGE MR imaging. J Magn Reson Imaging. 1991; 1(6):731-7. DOI: 10.1002/jmri.1880010621. View

12.

Ogawa S, Menon R, Tank D, Kim S, Merkle H, Ellermann J . Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J. 1993; 64(3):803-12. PMC: 1262394. DOI: 10.1016/S0006-3495(93)81441-3. View

13.

Yacoub E, Duong T, Van de Moortele P, Lindquist M, Adriany G, Kim S . Spin-echo fMRI in humans using high spatial resolutions and high magnetic fields. Magn Reson Med. 2003; 49(4):655-64. DOI: 10.1002/mrm.10433. View

14.

Feinberg D, Oshio K . GRASE (gradient- and spin-echo) MR imaging: a new fast clinical imaging technique. Radiology. 1991; 181(2):597-602. DOI: 10.1148/radiology.181.2.1924811. View

15.

Norris D . Spin-echo fMRI: The poor relation?. Neuroimage. 2012; 62(2):1109-15. DOI: 10.1016/j.neuroimage.2012.01.003. View

16.

Balu N, Yarnykh V, Chu B, Wang J, Hatsukami T, Yuan C . Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI. Magn Reson Med. 2010; 65(3):627-37. PMC: 3042490. DOI: 10.1002/mrm.22642. View

17.

Triantafyllou C, Hoge R, Krueger G, Wiggins C, Potthast A, Wiggins G . Comparison of physiological noise at 1.5 T, 3 T and 7 T and optimization of fMRI acquisition parameters. Neuroimage. 2005; 26(1):243-50. DOI: 10.1016/j.neuroimage.2005.01.007. View

18.

Parrish T, Hu X . A new T2 preparation technique for ultrafast gradient-echo sequence. Magn Reson Med. 1994; 32(5):652-7. DOI: 10.1002/mrm.1910320515. View

19.

Wang J, Yarnykh V, Hatsukami T, Chu B, Balu N, Yuan C . Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn Reson Med. 2007; 58(5):973-81. DOI: 10.1002/mrm.21385. View

20.

Poser B, Norris D . Fast spin echo sequences for BOLD functional MRI. MAGMA. 2007; 20(1):11-7. PMC: 2798036. DOI: 10.1007/s10334-006-0063-x. View