Haplotype-based Case-control Study of DNA Repair Gene XRCC3 and Hepatocellular Carcinoma Risk in a Chinese Population

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Dec 6

PMID 24307625

Citations 5

Authors

Hong-Chun Luo

Hong-Bin Zhang

Xiao-Juan Xin

Wen-Xiang Huang

Affiliations

Soon will be listed here.

Abstract

Previous studies indicated that the human X-ray repair complementing group 3 gene (XRCC3) plays an important role in hepatocellular carcinoma (HCC) susceptibility. We aimed to investigate the association of XRCC3 genetic polymorphism with HCC risk. This study was conducted in a Chinese Han population consisting of 300 HCC cases and 300 sex- and age-matched cancer-free controls. Three genetic variants (rs861539, rs12432907, and rs861537) were genotyped by the TaqMan® SNP Genotyping Assay. Our findings suggested that the TT genotype and T allele from rs861539 genetic variants were statistically associated with HCC risk. The TT genotype was statistically associated with the increased risk of HCC compared to CC wild genotype (P < 0.001). And the T allele was more common in the HCC patients than that in the control subjects. (OR = 1.97, 95% confidence interval (CI) 1.457 ~ 2.659, P < 0.001). Haplotype-based case-control study analysis indicated that TTG haplotype was more frequent in HCC groups than in the control group (odds ratio (OR) = 1.967, 95% CI 1.456 ~ 2.658); however, the CTG haplotype is more common in the control group than that in the HCC group (OR = 0.550, 95 % CI 0.430 ~ 0.703; P < 0.001). Our data indicated that genetic variants of the XRCC3 gene were statistically associated with HCC risk in a Chinese population.

Citing Articles

Comprehensive investigating of MMR gene in hepatocellular carcinoma with chronic hepatitis B virus infection in Han Chinese population.

Ma N, Jin A, Sun Y, Jin Y, Sun Y, Xiao Q Front Oncol. 2023; 13:1124459.

PMID: 37035153 PMC: 10079871. DOI: 10.3389/fonc.2023.1124459.

The association of six non-synonymous variants in three DNA repair genes with hepatocellular carcinoma risk: a meta-analysis.

Shi Y, Wang B, Xu B, Jiang D, Zhao D, Ji M J Cell Mol Med. 2016; 20(11):2056-2063.

PMID: 27306318 PMC: 5082408. DOI: 10.1111/jcmm.12896.

Genetic polymorphism of HLA-DQ confers susceptibility to hepatitis B virus-related hepatocellular carcinoma: a case-control study in Han population in China.

Gao X, Liu W, Zhang X, Tang L, Wang L, Yan L Tumour Biol. 2016; 37(9):12103-12111.

PMID: 27209411 DOI: 10.1007/s13277-016-5077-z.

Polymorphisms of homologous recombination RAD51, RAD51B, XRCC2, and XRCC3 genes and the risk of prostate cancer.

Nowacka-Zawisza M, Wisnik E, Wasilewski A, Skowronska M, Forma E, Brys M Anal Cell Pathol (Amst). 2015; 2015:828646.

PMID: 26339569 PMC: 4538310. DOI: 10.1155/2015/828646.

Genetic polymorphisms in antioxidant enzyme genes and susceptibility to hepatocellular carcinoma in Chinese population: a case-control study.

Su S, He K, Li J, Wu J, Zhang M, Feng C Tumour Biol. 2015; 36(6):4627-32.

PMID: 25894370 DOI: 10.1007/s13277-015-3110-2.

References

Duan C, Zhang W, Lu J, Wu H, Liu M, Zhu W . DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk. Tumour Biol. 2013; 34(5):2827-34. DOI: 10.1007/s13277-013-0841-9. View

But D, Lai C, Yuen M . Natural history of hepatitis-related hepatocellular carcinoma. World J Gastroenterol. 2008; 14(11):1652-6. PMC: 2695904. DOI: 10.3748/wjg.14.1652. View

Girard P, Graindorge D, Smirnova V, Rigolet P, Francesconi S, Scanlon S . Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization. PLoS One. 2013; 8(10):e75751. PMC: 3793007. DOI: 10.1371/journal.pone.0075751. View

Ng J, Wu J . Hepatitis B- and hepatitis C-related hepatocellular carcinomas in the United States: similarities and differences. Hepat Mon. 2012; 12(10 HCC):e7635. PMC: 3517810. DOI: 10.5812/hepatmon.7635. View

Gulnaz A, Sayyed A, Amin F, Khan A, Aslam M, Shaikh R . Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus. Eur J Gastroenterol Hepatol. 2012; 25(2):166-79. DOI: 10.1097/MEG.0b013e328359a775. View

Schutte K, Bornschein J, Malfertheiner P . Hepatocellular carcinoma--epidemiological trends and risk factors. Dig Dis. 2009; 27(2):80-92. DOI: 10.1159/000218339. View

Parkin D, Bray F, Ferlay J, Pisani P . Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55(2):74-108. DOI: 10.3322/canjclin.55.2.74. View

Parkin D . Global cancer statistics in the year 2000. Lancet Oncol. 2002; 2(9):533-43. DOI: 10.1016/S1470-2045(01)00486-7. View

Xie X, Ma Y, Fu Z, Yang Y, Ma X, Chen B . Haplotype analysis of the CYP8A1 gene associated with myocardial infarction. Clin Appl Thromb Hemost. 2009; 15(5):574-80. DOI: 10.1177/1076029608329581. View

10.

Yuen M, Hou J, Chutaputti A . Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol. 2009; 24(3):346-53. DOI: 10.1111/j.1440-1746.2009.05784.x. View

11.

Llovet J, Burroughs A, Bruix J . Hepatocellular carcinoma. Lancet. 2003; 362(9399):1907-17. DOI: 10.1016/S0140-6736(03)14964-1. View

12.

Han X, Xing Q, Li Y, Sun J, Ji H, Huazheng P . Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Hepatogastroenterology. 2012; 59(119):2285-9. DOI: 10.5754/hge12096. View

13.

Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z . A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 2009; 19(4):519-23. DOI: 10.1038/cr.2009.33. View

14.

Wu J, Zhang W, Xu A, Zhang L, Yan T, Li Z . Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. Genet Test Mol Biomarkers. 2013; 17(8):595-600. PMC: 3732435. DOI: 10.1089/gtmb.2013.0031. View

15.

Zeng X, Liu S, Yu H, Ji L, Li L, Huang J . DNA repair capacity, DNA-strand break repair gene polymorphisms, and the incidence of hepatocellular carcinoma in southwestern Guangxi of China. DNA Cell Biol. 2012; 31(8):1384-91. PMC: 3405453. DOI: 10.1089/dna.2012.1646. View

16.

Shi Y, He L . SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005; 15(2):97-8. DOI: 10.1038/sj.cr.7290272. View

17.

Liu C, Wang H . XRCC3 T241M polymorphism is associated risk of hepatocellular carcinoma in the Chinese. Tumour Biol. 2013; 34(4):2249-54. DOI: 10.1007/s13277-013-0765-4. View

18.

Parikh S, Hyman D . Hepatocellular cancer: a guide for the internist. Am J Med. 2007; 120(3):194-202. DOI: 10.1016/j.amjmed.2006.11.020. View

19.

Lai C, Hsieh L, Sung F, Tang R, Bai C, Wu F . Tumor site- and stage-specific associations between allelic variants of glutathione S-transferase and DNA-repair genes and overall survival in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. PLoS One. 2013; 8(7):e69039. PMC: 3720885. DOI: 10.1371/journal.pone.0069039. View

20.

Hoenerhoff M, Pandiri A, Snyder S, Hong H, Ton T, Peddada S . Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways. Toxicol Pathol. 2012; 41(6):826-41. PMC: 4799723. DOI: 10.1177/0192623312467520. View