Association of Epidermal Growth Factor and Epidermal Growth Factor Receptor Polymorphisms with the Risk of Hepatitis B Virus-related Hepatocellular Carcinoma in the Population of North China

Overview

Journal Genet Test Mol Biomarkers

Specialties Genetics
Molecular Biology

Date 2013 Jun 25

PMID 23790025

Citations 13

Authors

Jia Wu

Wei Zhang

Aiqiang Xu

Li Zhang

Tao Yan

Zhuo Li

XiaoPan Wu

XiLin Zhu

Juan Ma

Ke Li

Hui Li

Ying Liu

Affiliations

Soon will be listed here.

Abstract

Background: Hepatocellular carcinoma (HCC) is a common solid malignant tumor occurring worldwide that leads to the third largest cause of death compared to other cancers. Genetic and environmental factors are involved in the pathogenesis of HCC. Epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) can stimulate the proliferation of epidermal and epithelial cells. The EGF signal pathway has a relationship with the growth of the embryo, tissue repairing, and tumorigenesis.

Methods: In this study, 416 patients with hepatitis B virus infection (HBV)-related HCC and 645 individuals who had never been infected with HBV of the Chinese Han population were enrolled. Eight single-nucleotide polymorphisms (SNPs), whose minor allele frequency >20% in the EGF and EGFR genes, were genotyped to examine their associations with hepatocarcinogenesis. Genotyping experiments were carried out using TaqMan.

Results: There were significant differences in genotype distributions (p=0.005) and allele frequencies (p=0.001, odds ratio [OR]=1.43, 95% confidence interval [CI]=1.15-1.79) of rs11569017 in the EGF gene between the HCC and control groups. After binary logistic regression to determine independent factors for susceptibility to HCC under an additive model, rs11569017 was still independently associated with the susceptibility to HCC (p=0.021, OR=1.48, 95% CI=1.06-2.07), but no significant differences in other SNPs were found. Additionally, the haplotype T-G constructed by rs11569017 and rs4444903 of the EGF gene might increase the risk of HBV-related HCC (p=0.002, OR=1.44, 95% CI=1.15-1.82).

Conclusion: The rs11569017 T allele was associated with susceptibility to HBV-related HCC.

Citing Articles

Safety, Tolerability, and Serum/Tear Pharmacokinetics of Human Recombinant Epidermal Growth Factor Eyedrops in Healthy Subjects.

Yoo H, Yoon S, Jang I, Yu K, Hyon J, Hwang J Pharmaceuticals (Basel). 2022; 15(11).

PMID: 36355484 PMC: 9697941. DOI: 10.3390/ph15111312.

EGF rs4444903 polymorphism is associated with risk of HCV-related cirrhosis and HBV/HCV-related hepatocellular carcinoma.

Wang J, Zhong Y, Meng G Int J Clin Oncol. 2021; 26(11):2053-2064.

PMID: 34291370 DOI: 10.1007/s10147-021-01994-w.

Association between epidermal growth factor (EGF) and EGF receptor gene polymorphisms and end-stage renal disease and acute renal allograft rejection in a Korean population.

Kim B, Kim S, Heo K, Bae K, Jeong K, Lee S Ren Fail. 2020; 42(1):98-106.

PMID: 31906817 PMC: 6968622. DOI: 10.1080/0886022X.2019.1710535.

Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population.

Kim S, Park H, Choi H, Yoo K, Chung J Int Neurourol J. 2017; 20(4):363-370.

PMID: 28043105 PMC: 5209572. DOI: 10.5213/inj.1632538.269.

Application of a Combined Model with Autoregressive Integrated Moving Average (ARIMA) and Generalized Regression Neural Network (GRNN) in Forecasting Hepatitis Incidence in Heng County, China.

Wei W, Jiang J, Liang H, Gao L, Liang B, Huang J PLoS One. 2016; 11(6):e0156768.

PMID: 27258555 PMC: 4892637. DOI: 10.1371/journal.pone.0156768.

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