Novel Putative Mechanisms to Link Circadian Clocks to Healthy Aging

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2013 Dec 4

PMID 24297467

Citations 2

Authors

Aurel Popa-Wagner

Bogdan Catalin

Ana-Maria Buga

Affiliations

Soon will be listed here.

Abstract

The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.

Citing Articles

Self-perceived health in functionally independent older people: associated factors.

Machon M, Vergara I, Dorronsoro M, Vrotsou K, Larranaga I BMC Geriatr. 2016; 16:66.

PMID: 26961707 PMC: 4784324. DOI: 10.1186/s12877-016-0239-9.

Circadian gene variants in cancer.

Kettner N, Katchy C, Fu L Ann Med. 2014; 46(4):208-20.

PMID: 24901356 PMC: 4153443. DOI: 10.3109/07853890.2014.914808.

References

Huang W, Ramsey K, Marcheva B, Bass J . Circadian rhythms, sleep, and metabolism. J Clin Invest. 2011; 121(6):2133-41. PMC: 3104765. DOI: 10.1172/JCI46043. View

Duncan M, Smith J, Franklin K, Beckett T, Murphy M, St Clair D . Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease. Exp Neurol. 2012; 236(2):249-58. DOI: 10.1016/j.expneurol.2012.05.011. View

Hughes M, DiTacchio L, Hayes K, Vollmers C, Pulivarthy S, Baggs J . Harmonics of circadian gene transcription in mammals. PLoS Genet. 2009; 5(4):e1000442. PMC: 2654964. DOI: 10.1371/journal.pgen.1000442. View

Weaver D . The suprachiasmatic nucleus: a 25-year retrospective. J Biol Rhythms. 1998; 13(2):100-12. DOI: 10.1177/074873098128999952. View

Bonaconsa M, Colavito V, Pifferi F, Aujard F, Schenker E, Dix S . Cell clocks and neuronal networks: neuron ticking and synchronization in aging and aging-related neurodegenerative disease. Curr Alzheimer Res. 2013; 10(6):597-608. DOI: 10.2174/15672050113109990004. View

Lin J, Handschin C, Spiegelman B . Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005; 1(6):361-70. DOI: 10.1016/j.cmet.2005.05.004. View

Gibson E, Williams 3rd W, Kriegsfeld L . Aging in the circadian system: considerations for health, disease prevention and longevity. Exp Gerontol. 2008; 44(1-2):51-6. PMC: 2636858. DOI: 10.1016/j.exger.2008.05.007. View

Kondratov R, Kondratova A, Gorbacheva V, Vykhovanets O, Antoch M . Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 2006; 20(14):1868-73. PMC: 1522083. DOI: 10.1101/gad.1432206. View

Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F . SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2):317-28. DOI: 10.1016/j.cell.2008.06.050. View

10.

Bass J, Takahashi J . Circadian integration of metabolism and energetics. Science. 2010; 330(6009):1349-54. PMC: 3756146. DOI: 10.1126/science.1195027. View

11.

Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U . The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002; 110(2):251-60. DOI: 10.1016/s0092-8674(02)00825-5. View

12.

Rubinsztein D, Marino G, Kroemer G . Autophagy and aging. Cell. 2011; 146(5):682-95. DOI: 10.1016/j.cell.2011.07.030. View

13.

Kume K, Zylka M, Sriram S, Shearman L, Weaver D, Jin X . mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999; 98(2):193-205. DOI: 10.1016/s0092-8674(00)81014-4. View

14.

Rattan S . Synthesis, modification and turnover of proteins during aging. Adv Exp Med Biol. 2010; 694:1-13. DOI: 10.1007/978-1-4419-7002-2_1. View

15.

Solt L, Wang Y, Banerjee S, Hughes T, Kojetin D, Lundasen T . Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012; 485(7396):62-8. PMC: 3343186. DOI: 10.1038/nature11030. View

16.

Canaple L, Rambaud J, Dkhissi-Benyahya O, Rayet B, Tan N, Michalik L . Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol. 2006; 20(8):1715-27. DOI: 10.1210/me.2006-0052. View

17.

Lin J, Liu C, Li S . Integration of energy metabolism and the mammalian clock. Cell Cycle. 2008; 7(4):453-7. DOI: 10.4161/cc.7.4.5442. View

18.

Coogan A, Schutova B, Husung S, Furczyk K, Baune B, Kropp P . The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities. Biol Psychiatry. 2013; 74(5):333-9. DOI: 10.1016/j.biopsych.2012.11.021. View

19.

Ryazanov A, Nefsky B . Protein turnover plays a key role in aging. Mech Ageing Dev. 2001; 123(2-3):207-13. DOI: 10.1016/s0047-6374(01)00337-2. View

20.

Chang H, Guarente L . SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell. 2013; 153(7):1448-60. PMC: 3748806. DOI: 10.1016/j.cell.2013.05.027. View