Small Molecules Enable OCT4-mediated Direct Reprogramming into Expandable Human Neural Stem Cells

Overview

Journal Cell Res

Specialty Cell Biology

Date 2013 Dec 4

PMID 24296783

Citations 70

Authors

Saiyong Zhu

Rajesh Ambasudhan

Woong Sun

Hyun Jung Kim

Maria Talantova

Xiaojing Wang

Mingliang Zhang

Yu Zhang

Timothy Laurent

James Parker

Han-Seop Kim

Jeffrey D Zaremba

Sofiyan Saleem

Sara Sanz-Blasco

Eliezer Masliah

Scott R McKercher

Yee Sook Cho

Stuart A Lipton

Janghwan Kim

Sheng Ding

Affiliations

Soon will be listed here.

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References

Pang Z, Yang N, Vierbuchen T, Ostermeier A, Fuentes D, Yang T . Induction of human neuronal cells by defined transcription factors. Nature. 2011; 476(7359):220-3. PMC: 3159048. DOI: 10.1038/nature10202. View

Wang L, Wang L, Huang W, Su H, Xue Y, Su Z . Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods. 2012; 10(1):84-9. DOI: 10.1038/nmeth.2283. View

Kim J, Ambasudhan R, Ding S . Direct lineage reprogramming to neural cells. Curr Opin Neurobiol. 2012; 22(5):778-84. PMC: 4945246. DOI: 10.1016/j.conb.2012.05.001. View

Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S . A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011; 8(5):409-12. DOI: 10.1038/nmeth.1591. View

Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C . Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2012; 10(1):77-83. PMC: 3531579. DOI: 10.1038/nmeth.2255. View

Li J, Huang N, Zou J, Laurent T, Lee J, Okogbaa J . Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol. 2013; 33(6):1366-75. PMC: 3898631. DOI: 10.1161/ATVBAHA.112.301167. View

Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P . Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A. 2011; 108(20):8299-304. PMC: 3100988. DOI: 10.1073/pnas.1014041108. View

Zhu S, Wei W, Ding S . Chemical strategies for stem cell biology and regenerative medicine. Annu Rev Biomed Eng. 2011; 13:73-90. DOI: 10.1146/annurev-bioeng-071910-124715. View

Ring K, Tong L, Balestra M, Javier R, Andrews-Zwilling Y, Li G . Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell. 2012; 11(1):100-9. PMC: 3399516. DOI: 10.1016/j.stem.2012.05.018. View

10.

Lu J, Liu H, Huang C, Chen H, Du Z, Liu Y . Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep. 2013; 3(5):1580-91. PMC: 3786191. DOI: 10.1016/j.celrep.2013.04.004. View