T-cell Costimulatory Blockade in Organ Transplantation

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2013 Dec 4

PMID 24296352

Citations 8

Authors

Jonathan S Maltzman

Laurence A Turka

Affiliations

Soon will be listed here.

Abstract

Before it became possible to derive T-cell lines and clones, initial experimentation on the activation requirements of T lymphocytes was performed on transformed cell lines, such as Jurkat. These studies, although technically correct, proved misleading as most transformed T cells can be activated by stimulation of the clonotypic T-cell receptor (TCR) alone. In contrast, once it became possible to study nontransformed T cells, it quickly became clear that TCR stimulation by itself is insufficient for optimal activation of naïve T cells, but in fact, induces a state of anergy. It then became clear that functional activation of T cells requires not only recognition of major histocompatibility complex (MHC) and peptide by the TCR, but also requires ligation of costimulatory receptors expressed on the cell surface.

Citing Articles

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