Alphavirus Replication in Cultured Cells and Infected Animals is Inhibited by Antiproteinase Agents

Overview

Journal Antiviral Res

Publisher Elsevier

Date 1986 Aug 1

PMID 2429615

Citations 1

Authors

O P Zhirnov

A V Ovcharenko

E E Melnikova

A G Bukrinskaya

Gaidamovich SYa

Affiliations

Soon will be listed here.

Abstract

The influence of different antiproteinase agents on alphavirus replication was examined. Sindbis virus multicycle replication in cultured cells was suppressed by N-tosyl-phenylalanine chloromethyl ketone (TPCK), an inhibitor of chymotrypsin-like proteinases, and by aprotinin, an inhibitor of a wide spectrum of proteinases. Antiviral activity of TPCK was also demonstrated in Sindbis virus-infected animals. Parenteral injections of TPCK in infected mice reduced virus titers in brain and blood. The possible mechanism(s) of antiviral action of the antiproteinase agents are discussed.

Citing Articles

Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C EMBO J. 1998; 17(5):1268-78.

PMID: 9482724 PMC: 1170475. DOI: 10.1093/emboj/17.5.1268.

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