Brain Creatine Depletion in Vegetarians? A Cross-sectional ¹H-magnetic Resonance Spectroscopy (¹H-MRS) Study

Overview

Journal Br J Nutr

Specialty Nutritional Sciences

Date 2013 Dec 3

PMID 24290771

Citations 13

Authors

Marina Yazigi Solis

Vitor de Salles Painelli

Guilherme Giannini Artioli

Hamilton Roschel

Maria Concepcion Otaduy

Bruno Gualano

Affiliations

Soon will be listed here.

Abstract

The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (¹H-MRS). Dietary Cr intake was assessed by 3 d food recalls. Vegetarians had lower dietary Cr intake than omnivores (0.03 (SD 0.01) v. 1.34 (SD 0.62) g/d, respectively; P=0.005). However, vegetarians and omnivores had comparable brain total Cr content (5.999 (SD 0.811) v. 5.917 (SD 0.665) IU, respectively; P=0.77). In conclusion, dietary Cr did not influence brain Cr content in healthy individuals, suggesting that in normal conditions brain is dependent on its own Cr synthesis.

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