Epigenomics and Allergic Disease

Overview

Journal Epigenomics

Specialty Genetics

Date 2013 Nov 29

PMID 24283882

Citations 14

Authors

Gabrielle A Lockett

Veeresh K Patil

Nelis Soto-Ramirez

Ali H Ziyab

John W Holloway

Wilfried Karmaus

Affiliations

Soon will be listed here.

Abstract

Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.

Citing Articles

Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy.

Han R, Zhu D, Sha J, Zhao B, Jin P, Meng C Cell Biosci. 2024; 14(1):89.

PMID: 38965641 PMC: 11225420. DOI: 10.1186/s13578-024-01270-0.

Comparison of the Concordance of Allergic Diseases between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data.

Lee E, Kim J, Choi H, Kang H, Lim H, Kim J J Pers Med. 2023; 13(5).

PMID: 37240891 PMC: 10220535. DOI: 10.3390/jpm13050721.

The emerging role of histone deacetylase 1 in allergic diseases.

Wang Y, Wang H Front Immunol. 2022; 13:1027403.

PMID: 36311721 PMC: 9597694. DOI: 10.3389/fimmu.2022.1027403.

Infant Feeding Practices During the First Postnatal Year and Risk of Asthma and Allergic Disease During the First 6 Years of Life.

Pelak G, Wiese A, Maskarinec J, Phillips W, Keim S Breastfeed Med. 2021; 16(7):539-546.

PMID: 33733866 PMC: 8290294. DOI: 10.1089/bfm.2020.0275.

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy.

Acevedo N, Alashkar Alhamwe B, Caraballo L, Ding M, Ferrante A, Garn H Nutrients. 2021; 13(3).

PMID: 33668787 PMC: 7996340. DOI: 10.3390/nu13030724.

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