Decoding the Role of DNA Methylation in Allergic Diseases: from Pathogenesis to Therapy

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2024 Jul 4

PMID 38965641

Authors

Ruiming Han

Dongdong Zhu

Jichao Sha

Boning Zhao

Peng Jin

Cuida Meng

Affiliations

Soon will be listed here.

Abstract

Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic dermatitis, and food allergies. These complex conditions arise from the intricate interplay between genetic and environmental factors and are known to contribute to socioeconomic burdens globally. Recent advancements in the study of allergic diseases have illuminated the crucial role of DNA methylation (DNAm) in their pathogenesis. This review explores the factors influencing DNAm in allergic diseases and delves into their mechanisms, offering valuable perspectives for clinicians. Understanding these epigenetic modifications aims to lay the groundwork for improved early prevention strategies. Moreover, our analysis of DNAm mechanisms in these conditions seeks to enhance diagnostic and therapeutic approaches, paving the way for more effective management of allergic diseases in the future.

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