Impacts of the Apoptosis Inhibitor of Macrophage (AIM) on Obesity-associated Inflammatory Diseases

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2013 Nov 28

PMID 24281248

Citations 20

Authors

Satoko Arai

Toru Miyazaki

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with various metabolic and cardiovascular diseases caused by chronic, low-grade inflammation that is initially observed in obese adipose tissue. In addition, many etiological studies in humans have shown a strong correlation between obesity and inflammatory autoimmune diseases. In this review, we focus on the involvement of apoptosis inhibitor of macrophage (AIM), a macrophage-derived blood protein, in both types of immune response. Through differential mechanisms, AIM thereby plays key roles in the pathogenesis of atherosclerosis, metabolic diseases, and obesity-associated autoimmune diseases. Thus, the regulation of blood AIM levels or AIM function has the potential to serve as a next-generation therapy against these inflammatory diseases brought about by modern lifestyle.

Citing Articles

Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M.

Chen Q, Ishii K, Mori H, Nishijima A, Arai S, Miyazaki T Nat Commun. 2024; 15(1):9387.

PMID: 39477921 PMC: 11525585. DOI: 10.1038/s41467-024-53615-5.

Administration of an antibody against apoptosis inhibitor of macrophage prevents aortic aneurysm progression in mice.

Fujii T, Yamawaki-Ogata A, Terazawa S, Narita Y, Mutsuga M Sci Rep. 2024; 14(1):15878.

PMID: 38982113 PMC: 11233551. DOI: 10.1038/s41598-024-66791-7.

The effects of apoptosis inhibitor of macrophage in kidney diseases.

Cao Y, Hu B, Fan Y, Wang W, Chi M, Nasser M Eur J Med Res. 2024; 29(1):21.

PMID: 38178221 PMC: 10765713. DOI: 10.1186/s40001-023-01597-3.

Absolute Quantification of Pan-Cancer Plasma Proteomes Reveals Unique Signature in Multiple Myeloma.

Kotol D, Woessmann J, Hober A, Alvez M, Tran Minh K, Ponten F Cancers (Basel). 2023; 15(19).

PMID: 37835457 PMC: 10571728. DOI: 10.3390/cancers15194764.

Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition.

Tanoue S, Kanmura S, Hinokuchi M, Arima S, Sasaki F, Hashimoto S Biomed Rep. 2022; 17(4):82.

PMID: 36158321 PMC: 9468806. DOI: 10.3892/br.2022.1565.

References

Davis J, Gabler N, Walker-Daniels J, Spurlock M . Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring). 2008; 16(6):1248-55. DOI: 10.1038/oby.2008.210. View

Tissot J, Sanchez J, Vuadens F, Scherl A, Schifferli J, Hochstrasser D . IgM are associated to Sp alpha (CD5 antigen-like). Electrophoresis. 2002; 23(7-8):1203-6. DOI: 10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1. View

Solinas G, Vilcu C, Neels J, Bandyopadhyay G, Luo J, Naugler W . JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007; 6(5):386-97. DOI: 10.1016/j.cmet.2007.09.011. View

Yusa S, Ohnishi S, Onodera T, Miyazaki T . AIM, a murine apoptosis inhibitory factor, induces strong and sustained growth inhibition of B lymphocytes in combination with TGF-beta1. Eur J Immunol. 1999; 29(4):1086-93. DOI: 10.1002/(SICI)1521-4141(199904)29:04<1086::AID-IMMU1086>3.0.CO;2-X. View

Girousse A, Langin D . Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models. Int J Obes (Lond). 2011; 36(4):581-94. DOI: 10.1038/ijo.2011.113. View

Wu Z, Rosen E, Brun R, Hauser S, Adelmant G, Troy A . Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell. 1999; 3(2):151-8. DOI: 10.1016/s1097-2765(00)80306-8. View

Winer D, Winer S, Shen L, Wadia P, Yantha J, Paltser G . B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011; 17(5):610-7. PMC: 3270885. DOI: 10.1038/nm.2353. View

Li Q, Zhou J, Lian Y, Zhang B, Branch V, Carr-Johnson F . Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin Exp Immunol. 2009; 159(3):281-91. PMC: 2819494. DOI: 10.1111/j.1365-2249.2009.04057.x. View

Ligtenberg A, Veerman E, Nieuw Amerongen A, Mollenhauer J . Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol Chem. 2007; 388(12):1275-89. DOI: 10.1515/BC.2007.158. View

10.

Resnick D, Pearson A, Krieger M . The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci. 1994; 19(1):5-8. DOI: 10.1016/0968-0004(94)90165-1. View

11.

Lafontan M . Advances in adipose tissue metabolism. Int J Obes (Lond). 2009; 32 Suppl 7:S39-51. DOI: 10.1038/ijo.2008.237. View

12.

Zechner R, Strauss J, Haemmerle G, Lass A, Zimmermann R . Lipolysis: pathway under construction. Curr Opin Lipidol. 2005; 16(3):333-40. DOI: 10.1097/01.mol.0000169354.20395.1c. View

13.

Heyman B . The immune complex: possible ways of regulating the antibody response. Immunol Today. 1990; 11(9):310-3. DOI: 10.1016/0167-5699(90)90126-t. View

14.

Allen C, Cyster J . Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol. 2008; 20(1):14-25. PMC: 2366796. DOI: 10.1016/j.smim.2007.12.001. View

15.

Olsnes S, Klingenberg O, Wiedlocha A . Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus. Physiol Rev. 2002; 83(1):163-82. DOI: 10.1152/physrev.00021.2002. View

16.

Lumeng C, Bodzin J, Saltiel A . Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117(1):175-84. PMC: 1716210. DOI: 10.1172/JCI29881. View

17.

He W, Barak Y, Hevener A, Olson P, Liao D, Le J . Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003; 100(26):15712-7. PMC: 307633. DOI: 10.1073/pnas.2536828100. View

18.

Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K . Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Cell Metab. 2010; 11(6):479-92. DOI: 10.1016/j.cmet.2010.04.013. View

19.

Keophiphath M, Rouault C, Divoux A, Clement K, Lacasa D . CCL5 promotes macrophage recruitment and survival in human adipose tissue. Arterioscler Thromb Vasc Biol. 2009; 30(1):39-45. DOI: 10.1161/ATVBAHA.109.197442. View

20.

Kantor A, Herzenberg L . Origin of murine B cell lineages. Annu Rev Immunol. 1993; 11:501-38. DOI: 10.1146/annurev.iy.11.040193.002441. View