The Roles of Adipose Tissue Macrophages in Human Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jun 27

PMID 35757707

Authors

Weizheng Liang

Yanxu Qi

Hongyang Yi

Chenyu Mao

Qingxue Meng

Hao Wang

Chunfu Zheng

Affiliations

Soon will be listed here.

Abstract

Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets.

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