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RNase III: Genetics and Function; Structure and Mechanism

Overview
Journal Annu Rev Genet
Publisher Annual Reviews
Specialty Genetics
Date 2013 Nov 27
PMID 24274754
Citations 93
Authors
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Abstract

RNase III is a global regulator of gene expression in Escherichia coli that is instrumental in the maturation of ribosomal and other structural RNAs. We examine here how RNase III itself is regulated in response to growth and other environmental changes encountered by the cell and how, by binding or processing double-stranded RNA (dsRNA) intermediates, RNase III controls the expression of genes. Recent insight into the mechanism of dsRNA binding and processing, gained from structural studies of RNase III, is reviewed. Structural studies also reveal new cleavage sites in the enzyme that can generate longer 3' overhangs.

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