Dietary Vitamin D Intake and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct Study

Overview

Journal Eur J Clin Nutr

Specialty Nutritional Sciences

Date 2013 Nov 21

PMID 24253760

Citations 7

Authors

S Abbas

J Linseisen

S Rohrmann

J W J Beulens

B Buijsse

P Amiano

E Ardanaz

B Balkau

H Boeing

F Clavel-Chapelon

G Fagherazzi

P W Franks

D Gavrila

S Grioni

R Kaaks

T J Key

K T Khaw

T Kuhn

A Mattiello

E Molina-Montes

P M Nilsson

K Overvad

J R Quiros

O Rolandsson

C Sacerdote

C Saieva

N Slimani

I Sluijs

A M W Spijkerman

A Tjonneland

R Tumino

D L van der A

R Zamora-Ros

S J Sharp

C Langenberg

N G Forouhi

E Riboli

N J Wareham

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation.

Subjects/methods: Using a case-cohort design, 11,245 incident cases of type 2 diabetes and a representative subcohort (N=15,798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires.

Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend=0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D.

Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

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