MiR-15a Inhibits Cell Proliferation and Epithelial to Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma by Down-regulating Bmi-1 Expression

Overview

Journal Cancer Lett

Specialty Oncology

Date 2013 Nov 21

PMID 24252251

Citations 50

Authors

Shixiang Guo

Xuejun Xu

Yichen Tang

Chaobin Zhang

Jian Li

Yongsheng Ouyang

Jingfang Ju

Ping Bie

Huaizhi Wang

Affiliations

Soon will be listed here.

Abstract

Purposes: To investigate whether miR-15a inhibits cell proliferation and epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) via the down-regulation of B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) expression.

Methods And Results: miR-15a and Bmi-1 expressions in normal pancreatic tissue and PDAC tissue were measured. The relationship between miR-15a and Bmi-1 expression was analyzed. We found that miR-15a suppressed the expression of Bmi-1 and PDAC cell proliferation; E-cadherin expression was visibly up-regulated after silencing Bmi-1 by transfecting miR-15a into PDAC cell line.

Conclusion: miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.

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