Chronic Oral Pelargonidin Alleviates Learning and Memory Disturbances in Streptozotocin Diabetic Rats

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2013 Nov 20

PMID 24250390

Citations 5

Authors

Mohammadali Mirshekar

Mehrdad Roghani

Mohsen Khalili

Tourandokht Baluchnejadmojarad

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. Due to the anti-diabetic and antioxidant activity of pelargonidin (PG), this research study was conducted to evaluate the efficacy of chronic oral PG on alleviating learning and memory disturbance in streptozotocin-diabetic rats. Male Wistar rats were divided into control, diabetic, PG-treated control and PG (single-and/or multiple-dose)-treated diabetic groups. PG was administered p.o. once at a dose of 10 mg/kg and/or multiple doses on alternate days for 8 weeks. For induction of diabetes, streptozotocin (STZ) was injected IP in a single dose of 60 mg/kg. For the evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of study using a passive avoidance test. Meanwhile, spatial memory was assessed in a Y-maze task. It was found that the alternation score of the diabetic rats was lower than the control (p < 0.05) and that single dose PG-treated diabetic rats (p < 0.05) showed a higher alternation score in comparison with the diabetic group. Regarding initial latency, there was no significant difference among the groups. In addition, diabetic and single-dose PG-treated diabetic rats developed a significant impairment in retention and recall in the passive avoidance test (p < 0.01), as was evident by a lower STL. Furthermore, the retention and recall of multiple-dose PG-treated diabetic rats was significantly higher in comparison with diabetic rats (p < 0.05). Therefore, it can be concluded that single-dose oral PG may attenuate spatial memory in the Y maze paradigm and multiple-dose chronic PG could improve retention and recall capability in the passive avoidance test in STZ-diabetic rats.

Citing Articles

Pelargonidin---Glucoside Encapsulated Pectin-Chitosan-Nanoliposomes Recovers Palmitic Acid-Induced Hepatocytes Injury.

Karim N, Islam Shishir M, Li Y, Zineb O, Mo J, Tangpong J Antioxidants (Basel). 2022; 11(4).

PMID: 35453309 PMC: 9025254. DOI: 10.3390/antiox11040623.

Protective effect of chronic administration of pelargonidin on neuronal apoptosis and memory process in amyloid-beta-treated rats.

Alisavari N, Soleimani-Asl S, Zarei M, Hashemi-Firouzi N, Shahidi S Avicenna J Phytomed. 2021; 11(4):407-416.

PMID: 34290971 PMC: 8264223. DOI: 10.22038/AJP.2021.17680.

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels.

Al-Ishaq R, Abotaleb M, Kubatka P, Kajo K, Busselberg D Biomolecules. 2019; 9(9).

PMID: 31480505 PMC: 6769509. DOI: 10.3390/biom9090430.

Grape seed proanthocyanidin extract and insulin prevents cognitive decline in type 1 diabetic rat by impacting Bcl-2 and Bax in the prefrontal cortex.

Sanna R, Muthangi S, B K C, Asha Devi S Metab Brain Dis. 2018; 34(1):103-117.

PMID: 30284105 DOI: 10.1007/s11011-018-0320-5.

Antidiabetic properties of dietary flavonoids: a cellular mechanism review.

Vinayagam R, Xu B Nutr Metab (Lond). 2015; 12:60.

PMID: 26705405 PMC: 4690284. DOI: 10.1186/s12986-015-0057-7.

References

Noda Y, Kaneyuki T, Mori A, Packer L . Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J Agric Food Chem. 2002; 50(1):166-71. DOI: 10.1021/jf0108765. View

Galer B, Gianas A, Jensen M . Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000; 47(2):123-8. DOI: 10.1016/s0168-8227(99)00112-6. View

Wisniewski K, Fedosiewicz-Wasiluk M, Holy Z, Car H, Grzeda E . Influence of NMDA, a potent agonist of glutamate receptors, on behavioral activity in 4-week streptozotocin-induced diabetic rats. Pol J Pharmacol. 2003; 55(3):345-51. View

Heitner J, Dickson D . Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. Neurology. 1997; 49(5):1306-11. DOI: 10.1212/wnl.49.5.1306. View

Malone J, Hanna S, Saporta S, Mervis R, Park C, Chong L . Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatr Diabetes. 2008; 9(6):531-9. DOI: 10.1111/j.1399-5448.2008.00431.x. View

Feldman E, Stevens M, Greene D . Pathogenesis of diabetic neuropathy. Clin Neurosci. 1997; 4(6):365-70. View

Cherian S, Augusti K . Antidiabetic effects of a glycoside of leucopelargonidin isolated from Ficus bengalensis Linn. Indian J Exp Biol. 1993; 31(1):26-9. View

Das A, Rai D, Dikshit M, Palit G, Nath C . Nature of stress: differential effects on brain acetylcholinesterase activity and memory in rats. Life Sci. 2005; 77(18):2299-311. DOI: 10.1016/j.lfs.2005.02.020. View

Ekstrom P, Tomlinson D . Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides. Exp Neurol. 1990; 109(2):200-3. DOI: 10.1016/0014-4886(90)90074-3. View

10.

Nitta A, Murai R, Suzuki N, Ito H, Nomoto H, Katoh G . Diabetic neuropathies in brain are induced by deficiency of BDNF. Neurotoxicol Teratol. 2002; 24(5):695-701. DOI: 10.1016/s0892-0362(02)00220-9. View

11.

FLOOD J, Mooradian A, Morley J . Characteristics of learning and memory in streptozocin-induced diabetic mice. Diabetes. 1990; 39(11):1391-8. DOI: 10.2337/diab.39.11.1391. View

12.

Machha A, Mustafa M . Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol. 2005; 46(1):36-40. DOI: 10.1097/01.fjc.0000162769.83324.c1. View

13.

Laight D, Carrier M, Anggard E . Antioxidants, diabetes and endothelial dysfunction. Cardiovasc Res. 2000; 47(3):457-64. DOI: 10.1016/s0008-6363(00)00054-7. View

14.

Greene D, Stevens M, Feldman E . Diabetic neuropathy: scope of the syndrome. Am J Med. 1999; 107(2B):2S-8S. DOI: 10.1016/s0002-9343(99)00007-8. View

15.

Parihar M, Chaudhary M, Shetty R, Hemnani T . Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera. J Clin Neurosci. 2004; 11(4):397-402. DOI: 10.1016/j.jocn.2003.09.008. View

16.

Alvarez E, Beauquis J, Revsin Y, Banzan A, Roig P, De Nicola A . Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes. Behav Brain Res. 2008; 198(1):224-30. DOI: 10.1016/j.bbr.2008.11.001. View

17.

Popovic M, Biessels G, Isaacson R, Gispen W . Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task. Behav Brain Res. 2001; 122(2):201-7. DOI: 10.1016/s0166-4328(01)00186-3. View

18.

Roy M, Sen S, Chakraborti A . Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification. Life Sci. 2008; 82(21-22):1102-10. DOI: 10.1016/j.lfs.2008.03.011. View

19.

Biessels G, Smale S, Duis S, Kamal A, Gispen W . The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats. J Neurol Sci. 2001; 182(2):99-106. DOI: 10.1016/s0022-510x(00)00456-1. View

20.

Biessels G, van der Heide L, Kamal A, Bleys R, Gispen W . Ageing and diabetes: implications for brain function. Eur J Pharmacol. 2002; 441(1-2):1-14. DOI: 10.1016/s0014-2999(02)01486-3. View