Antidiabetic Properties of Dietary Flavonoids: a Cellular Mechanism Review

Overview

Journal Nutr Metab (Lond)

Publisher Biomed Central

Date 2015 Dec 26

PMID 26705405

Citations 129

Authors

Ramachandran Vinayagam

Baojun Xu

Affiliations

Soon will be listed here.

Abstract

Background: Natural food products have been used for combating human diseases for thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones, flavonols, isoflavones and anthocyanidins have been proposed as effective supplements for management and prevention of diabetes and its long-term complications based on in vitro and animal models.

Aim: To summarize the roles of dietary flavonoids in diabetes management and their molecular mechanisms.

Findings: Tremendous studies have found that flavonoids originated from foods could improve glucose metabolism, lipid profile, regulating the hormones and enzymes in human body, further protecting human being from diseases like obesity, diabetes and their complications.

Conclusion: In the current review, we summarize recent progress in understanding the biological action, mechanism and therapeutic potential of the dietary flavonoids and its subsequent clinical outcomes in the field of drug discovery in management of diabetes mellitus.

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References

Kreft S, Knapp M, Kreft I . Extraction of rutin from buckwheat (Fagopyrum esculentumMoench) seeds and determination by capillary electrophoresis. J Agric Food Chem. 1999; 47(11):4649-52. DOI: 10.1021/jf990186p. View

Manuel y Keenoy B, Vertommen J, De Leeuw I . The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients. Diabetes Nutr Metab. 2000; 12(4):256-63. View

Hakkinen S, Karenlampi S, Heinonen I, Mykkanen H, Torronen A . Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem. 2000; 47(6):2274-9. DOI: 10.1021/jf9811065. View

van Acker F, Schouten O, Haenen G, van der Vijgh W, Bast A . Flavonoids can replace alpha-tocopherol as an antioxidant. FEBS Lett. 2000; 473(2):145-8. DOI: 10.1016/s0014-5793(00)01517-9. View

Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N . Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000; 130(9):2243-50. DOI: 10.1093/jn/130.9.2243. View

Liggins J, Bluck L, Runswick S, Atkinson C, Coward W, Bingham S . Daidzein and genistein content of fruits and nuts. J Nutr Biochem. 2000; 11(6):326-31. DOI: 10.1016/s0955-2863(00)00085-1. View

Sandborn W, Faubion W . Clinical pharmacology of inflammatory bowel disease therapies. Curr Gastroenterol Rep. 2000; 2(6):440-5. DOI: 10.1007/s11894-000-0005-0. View

Clement S, Krause U, Desmedt F, Tanti J, Behrends J, Pesesse X . The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001; 409(6816):92-7. DOI: 10.1038/35051094. View

Miean K, Mohamed S . Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem. 2001; 49(6):3106-12. DOI: 10.1021/jf000892m. View

10.

Kim Y, Leem K, Park J, Lee P, Ahn D, Lee B . Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J Ethnopharmacol. 2001; 77(2-3):183-8. DOI: 10.1016/s0378-8741(01)00283-5. View

11.

Butler M, McKay R, Popoff I, Gaarde W, Witchell D, Murray S . Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes. 2002; 51(4):1028-34. DOI: 10.2337/diabetes.51.4.1028. View

12.

Ross J, Kasum C . Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr. 2002; 22:19-34. DOI: 10.1146/annurev.nutr.22.111401.144957. View

13.

Kile B, Schulman B, Alexander W, Nicola N, Martin H, Hilton D . The SOCS box: a tale of destruction and degradation. Trends Biochem Sci. 2002; 27(5):235-41. DOI: 10.1016/s0968-0004(02)02085-6. View

14.

Yokozawa T, Kim H, Cho E, Choi J, Young Chung H . Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem. 2002; 50(19):5490-5. DOI: 10.1021/jf0202133. View

15.

Kaszubska W, Falls H, Schaefer V, Haasch D, Frost L, Hessler P . Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line. Mol Cell Endocrinol. 2002; 195(1-2):109-18. DOI: 10.1016/s0303-7207(02)00178-8. View

16.

Dhawan K, Kumar S, Sharma A . Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food. 2003; 5(1):43-8. DOI: 10.1089/109662002753723214. View

17.

Duncan B, Schmidt M, Pankow J, Ballantyne C, Couper D, Vigo A . Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2003; 52(7):1799-805. DOI: 10.2337/diabetes.52.7.1799. View

18.

Gumieniczek A . Effect of the new thiazolidinedione-pioglitazone on the development of oxidative stress in liver and kidney of diabetic rabbits. Life Sci. 2003; 74(5):553-62. DOI: 10.1016/j.lfs.2003.03.004. View

19.

Pickup J . Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004; 27(3):813-23. DOI: 10.2337/diacare.27.3.813. View

20.

Devendra D, Liu E, Eisenbarth G . Type 1 diabetes: recent developments. BMJ. 2004; 328(7442):750-4. PMC: 381328. DOI: 10.1136/bmj.328.7442.750. View