Vibrational Photoacoustic Tomography: Chemical Imaging Beyond the Ballistic Regime

Overview

Journal J Phys Chem Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Nov 14

PMID 24224071

Citations 8

Authors

Justin Rajesh Rajian

Rui Li

Pu Wang

Ji-Xin Cheng

Affiliations

Soon will be listed here.

Abstract

Proof-of-concept of vibrational photoacoustic tomography is demonstrated with a homebuilt Raman laser generating greater than 100 mJ of energy per pulse at 1197 nm wavelength. We employed this system for excitation of second overtone transition of C-H bonds. Vibrational photoacoustic signal from C-H rich polyethylene tube phantom placed under 3 cm thick chicken breast tissue was obtained with a signal to noise ratio of 2.5. Further, we recorded photoacoustic image of a polyethylene ring placed under 5 mm chicken tissue with excellent contrast. This development opens new opportunities of performing label free vibrational imaging in the deep tissue regime.

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