Dynamic Characteristics of Serotonin and Dopamine Metabolism in the Rainbow Trout Brain: a Regional Study Using Liquid Chromatography with Electrochemical Detection

Overview

Journal Fish Physiol Biochem

Specialty Biochemistry

Date 2013 Nov 14

PMID 24221982

Citations 4

Authors

C Saligaut

T Bailhache

G Salbert

B Breton

P Jego

Affiliations

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Abstract

Aminergic metabolism was studied in discrete brain regions of the postovulated female rainbow trout using a liquid chromatography electrochemical detection method. 3 Methoxytyramine (3MT) was the major dopaminergic catabolite, suggesting that catechol-o-methyl transferase is the main dopamine (DA) catabolic enzyme. Two populations of brain regions were found: one with a high DA content and low 3MT/DA ratio (hypothalamus and telencephalon), suggesting that these regions could present a high density of DA perikarya; the other with a high 3MT/DA ratio (pituitary, preoptic area, myelencephalon and optic tectum) suggesting that these regions could present a high density of DA axonal endings. 5 Hydroxytryptamine (5HT) content differed, but an homogeneous distribution of monoamine oxidase was found in different brain regions. High 5HT content was found in the hypothalamus and telencephalon; 5HT was however not detectable in the pituitary.

Citing Articles

Catecholamine synthesis in the rainbow trout (Oncorhynchus mykiss) brain: modulation of tyrosine hydroxylase activity.

Saligaut C, Bennani S, Bailhache T Fish Physiol Biochem. 2013; 11(1-6):139-44.

PMID: 24202470 DOI: 10.1007/BF00004560.

Tyrosine hydroxylase activity and dopamine turnover of rainbow trout (Oncorhynchus mykiss) brain: the special status of the hypothalamus.

Linard B, Bennani S, Jego P, Saligaut C Fish Physiol Biochem. 2013; 15(1):41-8.

PMID: 24193987 DOI: 10.1007/BF01874836.

Modulation of monoamine neurotransmitters in fighting fish Betta splendens exposed to waterborne phytoestrogens.

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Alterations in the brain monoaminergic neurotransmitters of rainbow trout related to naphthalene exposure at the beginning of vitellogenesis.

Gesto M, Tintos A, Alvarez R, Soengas J, Miguez J Fish Physiol Biochem. 2008; 35(3):453-65.

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