Quantification of Amide Proton Transfer Effect Pre- and Post-gadolinium Contrast Agent Administration

Overview

Journal J Magn Reson Imaging

Date 2013 Nov 12

PMID 24214526

Citations 15

Authors

Yee Kai Tee

Manus J Donahue

George W J Harston

Stephen J Payne

Michael A Chappell

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish to what extent Gd alters quantification of the APT effect.

Materials And Methods: Four patients with internal carotid stenosis were recruited. APT imaging was acquired pre- and post-contrast in two sessions (before and after surgery) to assess the extent of relaxation time, T1 , change on APT effect calculated using magnetization transfer ratio asymmetry analysis at offsets of ±3.5 ppm relative to water resonance. Statistical and modeling evaluations were performed on the pre- and post-contrast APT effect to study the sensitivity to contrast administration.

Results: Before surgery, the post-contrast T1 was estimated to drop <10% of the pre-value for the majority of the patients. After surgery, higher post-contrast T1 reductions were observed in all the patients (maximum decrease was about 20% of the pre-value). Consistent differences between pre- and post-contrast were seen in the APT effect quantified using the asymmetry measure in most regions of the brain, with significant differences found in the white matter at the group level and in 25% of the individual patient results.

Conclusion: APT imaging should be performed prior to Gd administration to avoid potential misinterpretation of the APT effect.

Citing Articles

Multipool-CEST and CEST-based pH assessment as predictive tools for glioma grading, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation in gliomas.

Zhang X, Lu J, Liu X, Sun P, Qin Q, Xiang Z Front Oncol. 2025; 14:1507335.

PMID: 39759149 PMC: 11695364. DOI: 10.3389/fonc.2024.1507335.

Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.

Simegn G, Sun P, Zhou J, Kim M, Reddy R, Zu Z NMR Biomed. 2024; 38(1):e5294.

PMID: 39532518 PMC: 11606773. DOI: 10.1002/nbm.5294.

3D amide proton transfer-weighted imaging may be useful for diagnosing early-stage breast cancer: a prospective monocentric study.

Li Y, Zhang Y, Tian L, Li J, Li H, Wang X Eur Radiol Exp. 2024; 8(1):41.

PMID: 38584248 PMC: 10999404. DOI: 10.1186/s41747-024-00439-z.

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.

Zhou J, Zaiss M, Knutsson L, Sun P, Ahn S, Aime S Magn Reson Med. 2022; 88(2):546-574.

PMID: 35452155 PMC: 9321891. DOI: 10.1002/mrm.29241.

Clinical translation of amide proton transfer (APT) MRI for ischemic stroke: a systematic review (2003-2020).

Foo L, Harston G, Mehndiratta A, Yap W, Hum Y, Lai K Quant Imaging Med Surg. 2021; 11(8):3797-3811.

PMID: 34341751 PMC: 8245939. DOI: 10.21037/qims-20-1339.

References

Jones R, Haraldseth O, Schjott J, Brurok H, Jynge P, Oksendal A . Effect of Gd-DTPA-BMA on magnetization transfer: application to rapid imaging of cardiac ischemia. J Magn Reson Imaging. 1993; 3(1):31-9. DOI: 10.1002/jmri.1880030108. View

Jin T, Wang P, Zong X, Kim S . MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med. 2012; 69(3):760-70. PMC: 3419318. DOI: 10.1002/mrm.24315. View

Hua J, Jones C, Blakeley J, Smith S, van Zijl P, Zhou J . Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain. Magn Reson Med. 2007; 58(4):786-93. PMC: 3707117. DOI: 10.1002/mrm.21387. View

Zhou J, Payen J, Wilson D, Traystman R, van Zijl P . Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med. 2003; 9(8):1085-90. DOI: 10.1038/nm907. View

Sharma P, Socolow J, Patel S, Pettigrew R, Oshinski J . Effect of Gd-DTPA-BMA on blood and myocardial T1 at 1.5T and 3T in humans. J Magn Reson Imaging. 2006; 23(3):323-30. PMC: 7166832. DOI: 10.1002/jmri.20504. View

Chappell M, Donahue M, Tee Y, Khrapitchev A, Sibson N, Jezzard P . Quantitative Bayesian model-based analysis of amide proton transfer MRI. Magn Reson Med. 2012; 70(2):556-67. PMC: 7334045. DOI: 10.1002/mrm.24474. View

Tee Y, Khrapitchev A, Sibson N, Payne S, Chappell M . Evaluating the use of a continuous approximation for model-based quantification of pulsed chemical exchange saturation transfer (CEST). J Magn Reson. 2012; 222:88-95. PMC: 3431007. DOI: 10.1016/j.jmr.2012.07.003. View

Jia G, Abaza R, Williams J, Zynger D, Zhou J, Shah Z . Amide proton transfer MR imaging of prostate cancer: a preliminary study. J Magn Reson Imaging. 2011; 33(3):647-54. PMC: 4287206. DOI: 10.1002/jmri.22480. View

Jenkinson M, Bannister P, Brady M, Smith S . Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002; 17(2):825-41. DOI: 10.1016/s1053-8119(02)91132-8. View

10.

Liu D, Zhou J, Xue R, Zuo Z, An J, Wang D . Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 tesla. Magn Reson Med. 2012; 70(4):1070-81. PMC: 3605209. DOI: 10.1002/mrm.24560. View

11.

van Zijl P, Yadav N . Chemical exchange saturation transfer (CEST): what is in a name and what isn't?. Magn Reson Med. 2011; 65(4):927-48. PMC: 3148076. DOI: 10.1002/mrm.22761. View

12.

Deoni S . High-resolution T1 mapping of the brain at 3T with driven equilibrium single pulse observation of T1 with high-speed incorporation of RF field inhomogeneities (DESPOT1-HIFI). J Magn Reson Imaging. 2007; 26(4):1106-11. DOI: 10.1002/jmri.21130. View

13.

Woessner D, Zhang S, Merritt M, Sherry A . Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med. 2005; 53(4):790-9. DOI: 10.1002/mrm.20408. View

14.

Caravan P . Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev. 2006; 35(6):512-23. DOI: 10.1039/b510982p. View

15.

Zhao X, Wen Z, Huang F, Lu S, Wang X, Hu S . Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T. Magn Reson Med. 2011; 66(4):1033-41. PMC: 3136645. DOI: 10.1002/mrm.22891. View

16.

Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R . Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2010; 17(1):130-4. PMC: 3058561. DOI: 10.1038/nm.2268. View

17.

Zhang Y, Brady M, Smith S . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001; 20(1):45-57. DOI: 10.1109/42.906424. View

18.

Zhao X, Wen Z, Zhang G, Huang F, Lu S, Wang X . Three-dimensional turbo-spin-echo amide proton transfer MR imaging at 3-Tesla and its application to high-grade human brain tumors. Mol Imaging Biol. 2012; 15(1):114-22. PMC: 3518606. DOI: 10.1007/s11307-012-0563-1. View

19.

Smith S . Fast robust automated brain extraction. Hum Brain Mapp. 2002; 17(3):143-55. PMC: 6871816. DOI: 10.1002/hbm.10062. View

20.

Sun P, Zhou J, Sun W, Huang J, van Zijl P . Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab. 2006; 27(6):1129-36. DOI: 10.1038/sj.jcbfm.9600424. View