Surgically Resected Gastric Metastasis of Pulmonary Squamous Cell Carcinoma

Overview

Journal World J Gastrointest Surg

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2013 Nov 2

PMID 24179627

Citations 14

Authors

Yong Il Kim

Byung Chul Kang

Sun Hee Sung

Affiliations

Soon will be listed here.

Abstract

Gastric metastasis of pulmonary carcinoma has been reported to range from 0.19%-5.1%. An autopsy review of cancer disclosed 1.7%-29.6% of gastric metastases, primarily from breast cancer, lung cancer and melanoma. A 71-year-old man was referred to our department because of persistent cough, sputum and sweating for 20 d. Chest posteroanterior view and chest computed tomography scan demonstrated an irregular tumor mass measuring 5.8 cm with central necrosis at the right lower lung. Bronchoscopic biopsy revealed pulmonary squamous carcinoma. Esophagogastroduodenoscopy revealed a huge bleeding ulcer at the body of the stomach and a biopsy diagnosed a metastatic lesion. We performed a palliative total gastrectomy, splenectomy and distal pancreatectomy. The patient did not receive any adjuvant chemotherapy due to his refusal. He was controlled conservatively and survived for 11 mo after surgery. Surgical resection may provide an option for safe palliative treatment. Although gastric metastasis from lung cancer is associated with dismal outcomes, a longer survival or more favorable outcome has been demonstrated in patients undergoing palliative surgical resection of the metastatic site. Considerable improvements in the understanding of metastatic diseases and therapeutic strategies are needed to improve the clinical outcome.

Citing Articles

Combined gastroscopic and laparoscopic resection of gastric metastatic adenosquamous carcinoma from lung: A case report.

Lin Y, Wu Y, Zou D, Luo X, Zhang S World J Gastrointest Surg. 2024; 16(9):3065-3073.

PMID: 39351550 PMC: 11438818. DOI: 10.4240/wjgs.v16.i9.3065.

Metastatic Gastric Tumors: Clinical and Endoscopic Features.

Hirano K, Nomura K, Ochiai Y, Hayasaka J, Suzuki Y, Mitsunaga Y Cureus. 2024; 16(4):e58678.

PMID: 38770512 PMC: 11103945. DOI: 10.7759/cureus.58678.

Clinicopathological features and differential diagnosis of gastric metastases.

Chen W, Liu C, Liu Y, Yuan J, Wang Z World J Surg Oncol. 2023; 21(1):258.

PMID: 37608278 PMC: 10463964. DOI: 10.1186/s12957-023-03100-y.

Gastric Metastasis of Primary Lung Cancer: Case Report and Systematic Review With Pooled Analysis.

Tang D, Lv J, Liu Z, Zhan S, Gao Y Front Oncol. 2022; 12:922016.

PMID: 35875072 PMC: 9304872. DOI: 10.3389/fonc.2022.922016.

Gastric metastasis and transformation of primary lung adenocarcinoma to small cell cancer after acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors: A case report.

Liu J, Xia L, Peng Y, Huang Y, Yang Z Medicine (Baltimore). 2021; 100(39):e27289.

PMID: 34596125 PMC: 8483845. DOI: 10.1097/MD.0000000000027289.

References

Garwood R, Sawyer M, Ledesma E, Foley E, Claridge J . A case and review of bowel perforation secondary to metastatic lung cancer. Am Surg. 2005; 71(2):110-6. View

Rossi G, Marchioni A, Romagnani E, Bertolini F, Longo L, Cavazza A . Primary lung cancer presenting with gastrointestinal tract involvement: clinicopathologic and immunohistochemical features in a series of 18 consecutive cases. J Thorac Oncol. 2007; 2(2):115-20. View

Kim M, Kook E, Ahn S, Jeon S, Yoon J, Han M . Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation. J Cancer Res Clin Oncol. 2008; 135(2):297-301. DOI: 10.1007/s00432-008-0424-0. View

Green L . Hematogenous metastases to the stomach. A review of 67 cases. Cancer. 1990; 65(7):1596-600. DOI: 10.1002/1097-0142(19900401)65:7<1596::aid-cncr2820650724>3.0.co;2-5. View

Hillers T, Sauve M, Guyatt G . Analysis of published studies on the detection of extrathoracic metastases in patients presumed to have operable non-small cell lung cancer. Thorax. 1994; 49(1):14-9. PMC: 474077. DOI: 10.1136/thx.49.1.14. View

Alpar S, Kurt O, Ucar N, Orsel O, Aydog G, Kurt B . A case of squamous cell lung carcinoma with gastric metastasis. South Med J. 2007; 99(11):1313-4. DOI: 10.1097/01.smj.0000240697.56774.45. View

Sileri P, DUgo S, Del Vecchio Blanco G, Lolli E, Franceschilli L, Formica V . Solitary metachronous gastric metastasis from pulmonary adenocarcinoma: Report of a case. Int J Surg Case Rep. 2012; 3(8):385-8. PMC: 3376723. DOI: 10.1016/j.ijscr.2012.04.017. View

Menuck L, AMBERG J . Metastatic disease involving the stomach. Am J Dig Dis. 1975; 20(10):903-13. DOI: 10.1007/BF01070875. View

Hishida T, Nagai K, Yoshida J, Nishimura M, Ishii G, Iwasaki M . Is surgical resection indicated for a solitary non-small cell lung cancer recurrence?. J Thorac Cardiovasc Surg. 2006; 131(4):838-42. DOI: 10.1016/j.jtcvs.2005.11.028. View

10.

Aokage K, Yoshida J, Ishii G, Takahashi S, Sugito M, Nishimura M . Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma. J Thorac Oncol. 2008; 3(7):796-9. DOI: 10.1097/JTO.0b013e31817c925c. View

11.

Berger A, Cellier C, Daniel C, Kron C, Riquet M, Barbier J . Small bowel metastases from primary carcinoma of the lung: clinical findings and outcome. Am J Gastroenterol. 1999; 94(7):1884-7. DOI: 10.1111/j.1572-0241.1999.01224.x. View

12.

De Palma G, Masone S, Rega M, Simeoli I, Donisi M, Addeo P . Metastatic tumors to the stomach: clinical and endoscopic features. World J Gastroenterol. 2006; 12(45):7326-8. PMC: 4087491. DOI: 10.3748/wjg.v12.i45.7326. View

13.

Yang C, Hwang J, Kang W, Chong I, Wang T, Sheu C . Gastro-intestinal metastasis of primary lung carcinoma: clinical presentations and outcome. Lung Cancer. 2006; 54(3):319-23. DOI: 10.1016/j.lungcan.2006.08.007. View

14.

Kim S, Ha H, Park S, Kang J, Kim K, Lee S . Gastrointestinal metastasis from primary lung cancer: CT findings and clinicopathologic features. AJR Am J Roentgenol. 2009; 193(3):W197-201. DOI: 10.2214/AJR.08.1907. View

15.

Benghalia K, Colardelle P, Chochon M, Bretagne S, Doll J . [Gastric metastasis revealing lung cancer]. Gastroenterol Clin Biol. 2009; 33(6-7):494-5. DOI: 10.1016/j.gcb.2009.02.042. View

16.

Lee M, Kim S, Soh J, Chung M, Lee Y . A solitary gastric metastasis from pulmonary adenocarcinoma: a case report. Thorax. 2010; 65(7):661-2. DOI: 10.1136/thx.2009.122382. View

17.

Shomura H, Nakano S, Funai T, Akabane H, Inagaki M, Yanagida N . [A case of metastasis to the stomach from primary adenocarcinoma of the lung cancer]. Gan To Kagaku Ryoho. 2011; 37(12):2481-3. View

18.

Yamamoto M, Matsuzaki K, Kusumoto H, Uchida H, Mine H, Kabashima A . Gastric metastasis from lung carcinoma. Case report. Hepatogastroenterology. 2002; 49(44):363-5. View

19.

ODA , Kondo H, Yamao T, Saito D, Ono H, Gotoda T . Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 2001; 33(6):507-10. DOI: 10.1055/s-2001-14960. View

20.

Koch B, Tannapfel A, Vieth M, Grun R . [Gastric metastasis from small cell lung cancer]. Pneumologie. 2009; 63(10):585-7. DOI: 10.1055/s-0029-1214905. View