Dipeptide Frequencies in Proteins and the CpG Deficiency in Vertebrate DNA

Overview

Journal J Mol Evol

Specialty Biochemistry

Date 2013 Nov 1

PMID 24173492

Citations 3

Authors

E Bullock

R A Elton

Affiliations

Soon will be listed here.

Abstract

Analysis of vertebrate protein sequences totalling 4040 residues shows that amino acids with a high proportion of codons ending in C occur with significantly reduced frequency before amino acids whose codons start with G. This effect is not shown by "control" bacterial protein sequences. The consequent implication of shortage of XXC. GXX codon pairs in vertebrate messenger RNA is discussed in relation to the extreme rarity of the base doublet CpG in vertebrate DNA.

Citing Articles

Choice of base at silent codon site 3 is not selectively neutral in eucaryotic structural genes: it maintains excess short runs of weak and strong hydrogen bonding bases.

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CpG frequency in large DNA segments.

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PMID: 6577204 DOI: 10.1007/BF02099976.

The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family.

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