Identification of a New Genotype of Torque Teno Mini Virus

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2013 Nov 1

PMID 24171716

Citations 11

Authors

Seyed Mohammad Jazaeri Farsani

Maarten F Jebbink

Martin Deijs

Marta Canuti

Karel A van Dort

Margreet Bakker

Bart P X Grady

Maria Prins

Formijn J van Hemert

Neeltje A Kootstra

Lia van der Hoek

Affiliations

Soon will be listed here.

Abstract

Background: Although human torque teno viruses (TTVs) were first discovered in 1997, still many associated aspects are not clarified yet. The viruses reveal a remarkable heterogeneity and it is possible that some genotypes are more pathogenic than others. The identification of all genotypes is essential to confirm previous pathogenicity data, and an unbiased search for novel viruses is needed to identify TTVs that might be related to disease.

Method: The virus discovery technique VIDISCA-454 was used to screen serum of 55 HIV-1 positive injecting drug users, from the Amsterdam Cohort Studies, in search for novel blood-blood transmittable viruses which are undetectable via normal diagnostics or panvirus-primer PCRs.

Results: A novel torque teno mini virus (TTMV) was identified in two patients and the sequence of the full genomes were determined. The virus is significantly different from the known TTMVs (< 40% amino acid identity in ORF1), yet it contains conserved characteristics that are also present in other TTMVs. The virus is chronically present in both patients, and these patients both suffered from a pneumococcal pneumonia during follow up and had extremely low B-cells counts.

Conclusion: We describe a novel TTMV which we tentatively named TTMV-13. Further research is needed to address the epidemiology and pathogenicity of this novel virus.

Citing Articles

Longitudinal anellome dynamics in the upper respiratory tract of children with acute respiratory tract infections.

Cao L, Ma Y, Wan Z, Li B, Tian W, Zhang C Virus Evol. 2023; 9(2):vead045.

PMID: 37674817 PMC: 10478798. DOI: 10.1093/ve/vead045.

Diversity and Long-Term Dynamics of Human Blood Anelloviruses.

Kaczorowska J, Deijs M, Klein M, Bakker M, Jebbink M, Sparreboom M J Virol. 2022; 96(11):e0010922.

PMID: 35575554 PMC: 9175625. DOI: 10.1128/jvi.00109-22.

Taxonomic update for mammalian anelloviruses (family Anelloviridae).

Varsani A, Opriessnig T, Celer V, Maggi F, Okamoto H, Blomstrom A Arch Virol. 2021; 166(10):2943-2953.

PMID: 34383165 DOI: 10.1007/s00705-021-05192-x.

Genome Sequences of Novel Torque Teno Viruses Identified in Human Brain Tissue.

Kraberger S, Mastroeni D, Delvaux E, Varsani A Microbiol Resour Announc. 2020; 9(37).

PMID: 32912920 PMC: 7484079. DOI: 10.1128/MRA.00924-20.

Viral Metagenomics on Cerebrospinal Fluid.

Edridge A, Deijs M, van Zeggeren I, Kinsella C, Jebbink M, Bakker M Genes (Basel). 2019; 10(5).

PMID: 31052348 PMC: 6562652. DOI: 10.3390/genes10050332.

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