Longitudinal Anellome Dynamics In the Upper Respiratory Tract Of children with Acute Respiratory Tract Infections

Overview

Journal Virus Evol

Publisher Oxford University Press

Date 2023 Sep 7

PMID 37674817

Authors

Le Cao

Yingying Ma

Zhenzhou Wan

Bing Li

Weimin Tian

Chiyu Zhang

Yanpeng Li

Affiliations

Soon will be listed here.

Abstract

Anelloviruses (AVs) are ubiquitous in humans and are the most abundant components of the commensal virome. Previous studies on the diversity, transmission, and persistence of AVs mainly focused on the blood or transplanted tissues from adults; however, the profile of the anellome in the respiratory tract in children are barely known. We investigated the anellome profile and their dynamics in the upper respiratory tract from a cohort of children with acute respiratory tract infections (ARTIs). Different to that in adult, is the most abundant genus, followed by . We found that the relative abundance of was higher in earlier time points, and in contrast, the abundance of was higher in later time points; these results might suggest that decreased with age and increased with age in childhood. No difference regarding the diversity and abundance of anellome was found between single and multiple ARTIs, consistent with the idea that AV is not associated with certain disease. Most AVs are transient, and a small proportion (8 per cent) of them were found to be possibly persistent, with persistence time ranging from 1 month to as long as 56 months. Furthermore, the individual respiratory anellome appeared to be unique and dynamic, and the replacement of existing AVs with new ones are common over different time points. These findings demonstrate that may be the early colonizer in children, and the individual respiratory anellome is unique, which are featured by both chronic infections and AV community replacement.

References

Cordey S, Laubscher F, Hartley M, Junier T, Keitel K, Docquier M . Blood virosphere in febrile Tanzanian children. Emerg Microbes Infect. 2021; 10(1):982-993. PMC: 8171259. DOI: 10.1080/22221751.2021.1925161. View

Spandole-Dinu S, Cimponeriu D, Craciun A, Radu I, Nica S, Toma M . Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies. BMC Infect Dis. 2018; 18(1):334. PMC: 6050727. DOI: 10.1186/s12879-018-3248-9. View

Bolger A, Lohse M, Usadel B . Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014; 30(15):2114-20. PMC: 4103590. DOI: 10.1093/bioinformatics/btu170. View

Kumata R, Ito J, Takahashi K, Suzuki T, Sato K . A tissue level atlas of the healthy human virome. BMC Biol. 2020; 18(1):55. PMC: 7269688. DOI: 10.1186/s12915-020-00785-5. View

Bedarida S, Dussol B, Signoli M, Biagini P . Analysis of Anelloviridae sequences characterized from serial human and animal biological samples. Infect Genet Evol. 2017; 53:89-93. DOI: 10.1016/j.meegid.2017.05.017. View

van Rijn A, Roos R, Dekker F, Rotmans J, Feltkamp M . Torque teno virus load as marker of rejection and infection in solid organ transplantation - A systematic review and meta-analysis. Rev Med Virol. 2022; 33(1):e2393. PMC: 10078304. DOI: 10.1002/rmv.2393. View

Jazaeri Farsani S, Jebbink M, Deijs M, Canuti M, van Dort K, Bakker M . Identification of a new genotype of Torque Teno Mini virus. Virol J. 2013; 10:323. PMC: 3819664. DOI: 10.1186/1743-422X-10-323. View

Maggi F, Pistello M, Vatteroni M, Presciuttini S, Marchi S, Isola P . Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection. J Virol. 2001; 75(24):11999-2004. PMC: 116095. DOI: 10.1128/JVI.75.24.11999-12004.2001. View

Li Y, Fu X, Ma J, Zhang J, Hu Y, Dong W . Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nat Commun. 2019; 10(1):2288. PMC: 6533328. DOI: 10.1038/s41467-019-10294-x. View

10.

Kaczorowska J, Deijs M, Klein M, Bakker M, Jebbink M, Sparreboom M . Diversity and Long-Term Dynamics of Human Blood Anelloviruses. J Virol. 2022; 96(11):e0010922. PMC: 9175625. DOI: 10.1128/jvi.00109-22. View

11.

Fu L, Niu B, Zhu Z, Wu S, Li W . CD-HIT: accelerated for clustering the next-generation sequencing data. Bioinformatics. 2012; 28(23):3150-2. PMC: 3516142. DOI: 10.1093/bioinformatics/bts565. View

12.

Arze C, Springer S, Dudas G, Patel S, Bhattacharyya A, Swaminathan H . Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome. Cell Host Microbe. 2021; 29(8):1305-1315.e6. DOI: 10.1016/j.chom.2021.07.001. View

13.

Taylor L, Keeler E, Bushman F, Collman R . The enigmatic roles of Anelloviridae and Redondoviridae in humans. Curr Opin Virol. 2022; 55:101248. DOI: 10.1016/j.coviro.2022.101248. View

14.

Li Y, Cao L, Ye M, Xu R, Chen X, Ma Y . Plasma Virome Reveals Blooms and Transmission of Anellovirus in Intravenous Drug Users with HIV-1, HCV, and/or HBV Infections. Microbiol Spectr. 2022; 10(4):e0144722. PMC: 9431549. DOI: 10.1128/spectrum.01447-22. View

15.

Zhong S, Yeo W, Tang M, Lin X, Mo F, Ho W . Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients. Ann N Y Acad Sci. 2001; 945:84-92. DOI: 10.1111/j.1749-6632.2001.tb03868.x. View

16.

Bagaglio S, Sitia G, Prati D, Cella D, Hasson H, Novati R . Mother-to-child transmission of TT virus: sequence analysis of non-coding region of TT virus in infected mother-infant pairs. Arch Virol. 2002; 147(4):803-12. DOI: 10.1007/s007050200027. View

17.

Ball J, Curran R, Berridge S, Grabowska A, Jameson C, Thomson B . TT virus sequence heterogeneity in vivo: evidence for co-infection with multiple genetic types. J Gen Virol. 1999; 80 ( Pt 7):1759-1768. DOI: 10.1099/0022-1317-80-7-1759. View

18.

Bal A, Destras G, Sabatier M, Pichon M, Regue H, Oriol G . Metagenomic Analysis Reveals High Abundance of Torque Teno Mini Virus in the Respiratory Tract of Children with Acute Respiratory Illness. Viruses. 2022; 14(5). PMC: 9143613. DOI: 10.3390/v14050955. View

19.

Maggi F, Pifferi M, Fornai C, Andreoli E, Tempestini E, Vatteroni M . TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol. 2003; 77(4):2418-25. PMC: 141071. DOI: 10.1128/jvi.77.4.2418-2425.2003. View

20.

Tekippe E, Wylie K, Deych E, Sodergren E, Weinstock G, Storch G . Increased prevalence of anellovirus in pediatric patients with fever. PLoS One. 2012; 7(11):e50937. PMC: 3511395. DOI: 10.1371/journal.pone.0050937. View