Inhibition of MiR-92b Suppresses Nonsmall Cell Lung Cancer Cells Growth and Motility by Targeting RECK

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2013 Oct 29

PMID 24162673

Citations 31

Authors

Lin Lei

Yaping Huang

Wenrong Gong

Affiliations

Soon will be listed here.

Abstract

microRNAs play critical roles in the progression and metastasis of nonsmall cell lung cancer (NSCLC). miR-92b acts as an oncogene in some malignancies; however, its role in NSCLC remains poorly understood. Here, we found that miR-92b was significantly increased in human NSCLC tissues and cell lines. Inhibition of miR-92b remarkably suppressed cell proliferation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified to be a target of miR-92b. Expression of miR-92b was negatively correlated with RECK in NSCLC tissues. Collectively, miR-92b might promote NSCLC cell growth and motility partially by inhibiting RECK.

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References

Ramalingam S, Owonikoko T, Khuri F . Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin. 2011; 61(2):91-112. DOI: 10.3322/caac.20102. View

Sengupta S, Nie J, Wagner R, Yang C, Stewart R, Thomson J . MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells. 2009; 27(7):1524-8. DOI: 10.1002/stem.84. View

Li N, Tang B, Zhu E, Li B, Zhuang Y, Yu S . Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK. FEBS Lett. 2012; 586(6):722-8. DOI: 10.1016/j.febslet.2012.01.025. View

Vosa U, Vooder T, Kolde R, Fischer K, Valk K, Tonisson N . Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer. Genes Chromosomes Cancer. 2011; 50(10):812-22. DOI: 10.1002/gcc.20902. View

Wang K, Wang X, Zou J, Zhang A, Wan Y, Pu P . miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. Neuro Oncol. 2013; 15(5):578-88. PMC: 3635522. DOI: 10.1093/neuonc/not004. View

Siegel R, Naishadham D, Jemal A . Cancer statistics, 2012. CA Cancer J Clin. 2012; 62(1):10-29. DOI: 10.3322/caac.20138. View

Haug B, Henriksen J, Buechner J, Geerts D, Tomte E, Kogner P . MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma. Carcinogenesis. 2011; 32(7):1005-12. DOI: 10.1093/carcin/bgr073. View

Lu X, Zhang S, Fang Y, Wang Z, Xie J, Zhan Q . Clinical significance of RECK promoter methylation in pancreatic ductal adenocarcinoma. Tumour Biol. 2013; 34(6):3339-43. DOI: 10.1007/s13277-013-0903-z. View

Tsuchida A, Ohno S, Wu W, Borjigin N, Fujita K, Aoki T . miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer. Cancer Sci. 2011; 102(12):2264-71. DOI: 10.1111/j.1349-7006.2011.02081.x. View

10.

Dalmasso G, Nguyen H, Yan Y, Laroui H, Charania M, Obertone T . MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010; 300(1):G52-9. PMC: 3025505. DOI: 10.1152/ajpgi.00394.2010. View

11.

Du Y, Dai D, Yang Z . Role of RECK methylation in gastric cancer and its clinical significance. World J Gastroenterol. 2010; 16(7):904-8. PMC: 2825339. DOI: 10.3748/wjg.v16.i7.904. View

12.

Ma Q, Jiang Q, Pu Q, Zhang X, Yang W, Wang Y . MicroRNA-143 inhibits migration and invasion of human non-small-cell lung cancer and its relative mechanism. Int J Biol Sci. 2013; 9(7):680-92. PMC: 3729010. DOI: 10.7150/ijbs.6623. View

13.

Ke Y, Zhao W, Xiong J, Cao R . Downregulation of miR-16 promotes growth and motility by targeting HDGF in non-small cell lung cancer cells. FEBS Lett. 2013; 587(18):3153-7. DOI: 10.1016/j.febslet.2013.08.010. View

14.

Clark J, Thomas D, Choong P, Dass C . RECK--a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer. Cancer Metastasis Rev. 2007; 26(3-4):675-83. DOI: 10.1007/s10555-007-9093-8. View

15.

Wang R, Wang Z, Yang J, Pan X, De W, Chen L . MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene. 2011; 30(23):2644-58. DOI: 10.1038/onc.2010.642. View

16.

Yates L, Norbury C, Gilbert R . The long and short of microRNA. Cell. 2013; 153(3):516-9. DOI: 10.1016/j.cell.2013.04.003. View

17.

Zhang N, Wei X, Xu L . miR-150 promotes the proliferation of lung cancer cells by targeting P53. FEBS Lett. 2013; 587(15):2346-51. DOI: 10.1016/j.febslet.2013.05.059. View

18.

Fendler A, Jung K . MicroRNAs as new diagnostic and prognostic biomarkers in urological tumors. Crit Rev Oncog. 2013; 18(4):289-302. DOI: 10.1615/critrevoncog.2013007176. View

19.

Guo F, Tian J, Lin Y, Jin Y, Wang L, Cui M . Serum microRNA-92 expression in patients with ovarian epithelial carcinoma. J Int Med Res. 2013; 41(5):1456-61. DOI: 10.1177/0300060513487652. View

20.

Zhang Y, Cheng S, Zhang G, Ma W, Liu Y, Zhao R . Low expression of RECK indicates a shorter survival for patients with invasive breast cancer. Cancer Sci. 2012; 103(6):1084-9. PMC: 7685079. DOI: 10.1111/j.1349-7006.2012.02265.x. View