The Effects of Perchlorate, Nitrate, and Thiocyanate on Free Thyroxine for Potentially Sensitive Subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys

Overview

Journal J Expo Sci Environ Epidemiol

Specialties Environmental Health
Public Health

Date 2013 Oct 24

PMID 24149973

Citations 18

Authors

Mina Suh

Liz Abraham

J Gregory Hixon

Deborah M Proctor

Affiliations

Soon will be listed here.

Abstract

Among women with urinary iodine concentration <100 μg/l in the 2001-2002 National Health and Nutrition Examination Survey (NHANES), urinary perchlorate was associated with significant changes in thyroid stimulating hormone and total thyroxine (T4). Although perchlorate, nitrate, and thiocyanate all potentially act to inhibit iodide uptake, free T4 was not found to be associated with exposure to these chemicals in the same data. Fetuses of pregnant mothers with iodine deficiency are thought to be a sensitive subpopulation for perchlorate exposure, but the potential associations between free T4 and exposure to these chemicals among pregnant mothers in NHANES 2001-2002 and 2007-2008 have not been specifically evaluated to date. This study investigates the potential associations between urinary perchlorate, nitrate, and thiocyanate and serum free T4 in individuals with low urinary iodine levels and pregnant women. Multivariate regression models of free T4 were conducted and included urinary perchlorate, nitrate, thiocyanate, and covariates known to have an impact on the thyroid (anti-thyroid peroxidase (TPO) antibodies, age, race/ethnicity, body mass index, and hours of fasting). Meta-analyses were also conducted on non-pregnant and on pregnant women from the two survey cycles. Urinary nitrate was associated with serum free T4 in non-pregnant women of NHANES 2001-2002 who had urinary iodine ≥100 μg/l. In the meta-analysis, urinary perchlorate, nitrate, and thiocyanate were significant predictors of serum free T4 in non-pregnant women. No association was found in men and pregnant women. TPO antibodies were significant predictors of free T4 among non-pregnant women only when the models included urinary perchlorate, nitrate, or thiocyanate. Risk assessment for perchlorate exposure should consider co-exposure to nitrate and thiocyanate.

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References

Lawrence J, Lamm S, Pino S, Richman K, Braverman L . The effect of short-term low-dose perchlorate on various aspects of thyroid function. Thyroid. 2000; 10(8):659-63. DOI: 10.1089/10507250050137734. View

Ward M, Kilfoy B, Weyer P, Anderson K, Folsom A, Cerhan J . Nitrate intake and the risk of thyroid cancer and thyroid disease. Epidemiology. 2010; 21(3):389-95. PMC: 2879161. DOI: 10.1097/EDE.0b013e3181d6201d. View

Clewell R, Merrill E, Yu K, Mahle D, Sterner T, Fisher J . Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling. Toxicol Sci. 2003; 74(2):416-36. DOI: 10.1093/toxsci/kfg147. View

Steinmaus C, Miller M, Howd R . Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001-2002 national health and nutrition examination survey. Environ Health Perspect. 2007; 115(9):1333-8. PMC: 1964908. DOI: 10.1289/ehp.10300. View

Huber D, Blount B, Mage D, Letkiewicz F, Kumar A, Allen R . Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data. J Expo Sci Environ Epidemiol. 2010; 21(4):395-407. DOI: 10.1038/jes.2010.31. View

De Groef B, Decallonne B, Van der Geyten S, Darras V, Bouillon R . Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. Eur J Endocrinol. 2006; 155(1):17-25. DOI: 10.1530/eje.1.02190. View

Barr D, Wilder L, Caudill S, Gonzalez A, Needham L, Pirkle J . Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005; 113(2):192-200. PMC: 1277864. DOI: 10.1289/ehp.7337. View

Yen P . Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001; 81(3):1097-142. DOI: 10.1152/physrev.2001.81.3.1097. View

Blount B, Pirkle J, Osterloh J, Valentin-Blasini L, Caldwell K . Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ Health Perspect. 2006; 114(12):1865-71. PMC: 1764147. DOI: 10.1289/ehp.9466. View

10.

McLanahan E, White P, Flowers L, Schlosser P . The use of PBPK models to inform human health risk assessment: case study on perchlorate and radioiodide human lifestage models. Risk Anal. 2013; 34(2):356-66. DOI: 10.1111/risa.12101. View

11.

Caldwell K, Makhmudov A, Ely E, Jones R, Wang R . Iodine status of the U.S. population, National Health and Nutrition Examination Survey, 2005–2006 and 2007–2008. Thyroid. 2011; 21(4):419-27. DOI: 10.1089/thy.2010.0077. View

12.

Wolff J . Perchlorate and the thyroid gland. Pharmacol Rev. 1998; 50(1):89-105. View

13.

Greer M, Goodman G, Pleus R, Greer S . Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans. Environ Health Perspect. 2002; 110(9):927-37. PMC: 1240994. DOI: 10.1289/ehp.02110927. View

14.

M Buratti D Xaiz G Caravelliand A Colombi . Validation of urinary thiocyanate as a biomarker of tobacco smoking. Biomarkers. 2013; 2(2):81-5. DOI: 10.1080/135475097231797. View

15.

Tonacchera M, Pinchera A, Dimida A, Ferrarini E, Agretti P, Vitti P . Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter. Thyroid. 2005; 14(12):1012-9. DOI: 10.1089/thy.2004.14.1012. View

16.

Lambert-Messerlian G, McClain M, Haddow J, Palomaki G, Canick J, Cleary-Goldman J . First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. Am J Obstet Gynecol. 2008; 199(1):62.e1-6. PMC: 2529146. DOI: 10.1016/j.ajog.2007.12.003. View

17.

Gibbs J, Van Landingham C . Urinary perchlorate excretion does not predict thyroid function among pregnant women. Thyroid. 2008; 18(7):807-8. DOI: 10.1089/thy.2007.0377. View

18.

Fisher J, Lumen A, Latendresse J, Mattie D . Extrapolation of hypothalamic-pituitary-thyroid axis perturbations and associated toxicity in rodents to humans: case study with perchlorate. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012; 30(1):81-105. DOI: 10.1080/10590501.2012.653889. View

19.

Moleti M, Trimarchi F, Vermiglio F . Doubts and Concerns about Isolated Maternal Hypothyroxinemia. J Thyroid Res. 2011; 2011:463029. PMC: 3134327. DOI: 10.4061/2011/463029. View

20.

Mervish N, Blount B, Valentin-Blasini L, Brenner B, Galvez M, Wolff M . Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children. J Expo Sci Environ Epidemiol. 2011; 22(2):212-8. PMC: 3288286. DOI: 10.1038/jes.2011.44. View