How Do Transporters Couple Solute Movements?

Overview

Journal Mol Membr Biol

Publisher Informa Healthcare

Specialties Biochemistry
Molecular Biology

Date 2013 Oct 24

PMID 24147977

Citations 12

Authors

Gary Rudnick

Affiliations

Soon will be listed here.

Abstract

Abstract The availability of high-resolution atomic structures for transport proteins provides unprecedented opportunities for understanding their mechanism of action. The details of conformational change can be deduced from these structures, especially when multiple conformations are available. However, the singular ability of transporters to couple the movement of one solute to that of another requires even more information than what is supplied by a crystal structure. This short commentary discusses how recent biochemical and biophysical studies are beginning to reveal how solute coupling is achieved.

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