Synthesis of QS-21-based Immunoadjuvants

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Oct 24

PMID 24147602

Citations 14

Authors

Pengfei Wang

Qipu Dai

Punith Thogaripally

Ping Zhang

Suzanne M Michalek

Affiliations

Soon will be listed here.

Abstract

Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) open the door to the pursuit of a new series of structurally defined QS-saponin-based synthetic adjuvants.

Citing Articles

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Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments.

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Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination.

Bhatnagar N, Kim K, Subbiah J, Park B, Wang P, Gill H Vaccines (Basel). 2022; 10(9).

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Natural and Synthetic Saponins as Vaccine Adjuvants.

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