Pulmonary MRI Contrast Using Surface Quadrupolar Relaxation (SQUARE) of Hyperpolarized (83)Kr

Overview

Journal Magn Reson Imaging

Publisher Elsevier

Specialty Radiology

Date 2013 Oct 23

PMID 24144493

Citations 6

Authors

Joseph S Six

Theodore Hughes-Riley

David M L Lilburn

Alan C Dorkes

Karl F Stupic

Dominick E Shaw

Peter G Morris

Ian P Hall

Galina E Pavlovskaya

Thomas Meersmann

Affiliations

Soon will be listed here.

Abstract

Hyperpolarized (83)Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the (83)Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched (83)Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized (83)Kr MRI after krypton inhalation. Different (83)Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized (83)Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.

Citing Articles

Multi-nuclear magnetic resonance spectroscopy: state of the art and future directions.

Wei Y, Yang C, Jiang H, Li Q, Che F, Wan S Insights Imaging. 2022; 13(1):135.

PMID: 35976510 PMC: 9382599. DOI: 10.1186/s13244-022-01262-z.

Hyperpolarized gas MRI in pulmonology.

Kern A, Vogel-Claussen J Br J Radiol. 2017; 91(1084):20170647.

PMID: 29271239 PMC: 5965996. DOI: 10.1259/bjr.20170647.

NMR Hyperpolarization Techniques of Gases.

Barskiy D, Coffey A, Nikolaou P, Mikhaylov D, Goodson B, Branca R Chemistry. 2016; 23(4):725-751.

PMID: 27711999 PMC: 5462469. DOI: 10.1002/chem.201603884.

Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.

Rogers N, Hill-Casey F, Stupic K, Six J, Lesbats C, Rigby S Proc Natl Acad Sci U S A. 2016; 113(12):3164-8.

PMID: 26961001 PMC: 4812722. DOI: 10.1073/pnas.1600379113.

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

Lilburn D, Lesbats C, Six J, Dubuis E, Yew-Booth L, Shaw D J R Soc Interface. 2015; 12(107).

PMID: 25994296 PMC: 4587540. DOI: 10.1098/rsif.2015.0192.

References

Salerno M, de Lange E, Altes T, Truwit J, Brookeman J, Mugler 3rd J . Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. Radiology. 2002; 222(1):252-60. DOI: 10.1148/radiol.2221001834. View

Thurlbeck W . Internal surface area and other measurements in emphysema. Thorax. 1967; 22(6):483-96. PMC: 471691. DOI: 10.1136/thx.22.6.483. View

Cleveland Z, Stupic K, Pavlovskaya G, Repine J, Wooten J, Meersmann T . Hyperpolarized 83Kr and 129Xe NMR relaxation measurements of hydrated surfaces: implications for materials science and pulmonary diagnostics. J Am Chem Soc. 2007; 129(6):1784-92. DOI: 10.1021/ja065994t. View

Hachulla A, Pontana F, Wemeau-Stervinou L, Khung S, Faivre J, Wallaert B . Krypton ventilation imaging using dual-energy CT in chronic obstructive pulmonary disease patients: initial experience. Radiology. 2012; 263(1):253-9. DOI: 10.1148/radiol.12111211. View

MASSARO G, Massaro D . Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med. 1997; 3(6):675-7. DOI: 10.1038/nm0697-675. View

Parra-Robles J, Ajraoui S, Deppe M, Parnell S, Wild J . Experimental investigation and numerical simulation of 3He gas diffusion in simple geometries: implications for analytical models of 3He MR lung morphometry. J Magn Reson. 2010; 204(2):228-38. DOI: 10.1016/j.jmr.2010.02.023. View

Gunther A, Siebert C, Schmidt R, Ziegler S, Grimminger F, Yabut M . Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am J Respir Crit Care Med. 1996; 153(1):176-84. DOI: 10.1164/ajrccm.153.1.8542113. View

Albert M, Cates G, Driehuys B, Happer W, Saam B, Springer Jr C . Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994; 370(6486):199-201. DOI: 10.1038/370199a0. View

Driehuys B, Cofer G, Pollaro J, Mackel J, Hedlund L, Johnson G . Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A. 2006; 103(48):18278-83. PMC: 1838742. DOI: 10.1073/pnas.0608458103. View

10.

Deninger A, Eberle B, Ebert M, Grossmann T, Hanisch G, Heil W . (3)he-MRI-based measurements of intrapulmonary p(O2) and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations. NMR Biomed. 2000; 13(4):194-201. DOI: 10.1002/1099-1492(200006)13:4<194::aid-nbm643>3.0.co;2-d. View

11.

Smith J, Travis S, Greenberg E, Welsh M . Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell. 1996; 85(2):229-36. DOI: 10.1016/s0092-8674(00)81099-5. View

12.

Raftery , Long , Meersmann , Grandinetti , Reven , PINES . High-field NMR of adsorbed xenon polarized by laser pumping. Phys Rev Lett. 1991; 66(5):584-587. DOI: 10.1103/PhysRevLett.66.584. View

13.

Sukstanskii A, Conradi M, Yablonskiy D . ³He lung morphometry technique: accuracy analysis and pulse sequence optimization. J Magn Reson. 2010; 207(2):234-41. PMC: 2993856. DOI: 10.1016/j.jmr.2010.09.005. View

14.

Stupic K, Elkins N, Pavlovskaya G, Repine J, Meersmann T . Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation. Phys Med Biol. 2011; 56(13):3731-48. PMC: 3249834. DOI: 10.1088/0031-9155/56/13/001. View

15.

SPENCE M, Rubin S, Dimitrov I, Ruiz E, Wemmer D, Pines A . Functionalized xenon as a biosensor. Proc Natl Acad Sci U S A. 2001; 98(19):10654-7. PMC: 58521. DOI: 10.1073/pnas.191368398. View

16.

Gentile T, Jones G, Thompson A, Rizi R, Roberts D, Dimitrov I . Demonstration of a compact compressor for application of metastability-exchange optical pumping of 3He to human lung imaging. Magn Reson Med. 2000; 43(2):290-4. DOI: 10.1002/(sici)1522-2594(200002)43:2<290::aid-mrm17>3.0.co;2-a. View

17.

Zhao L, Mulkern R, Tseng C, Williamson D, Patz S, Kraft R . Gradient-echo imaging considerations for hyperpolarized 129Xe MR. J Magn Reson B. 1996; 113:179-83. View

18.

Fischer M, Spector Z, Ishii M, Yu J, Emami K, Itkin M . Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI. Magn Reson Med. 2004; 52(4):766-73. DOI: 10.1002/mrm.20239. View

19.

Albert M, Balamore D, Kacher D, Venkatesh A, Jolesz F . Hyperpolarized (129)Xe T (1) in oxygenated and deoxygenated blood. NMR Biomed. 2000; 13(7):407-14. DOI: 10.1002/1099-1492(200011)13:7<407::aid-nbm661>3.0.co;2-1. View

20.

Mugler 3rd J, Altes T, Ruset I, Dregely I, Mata J, Miller G . Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A. 2010; 107(50):21707-12. PMC: 3003026. DOI: 10.1073/pnas.1011912107. View