Aging on a Different Scale--chronological Versus Pathology-related Aging

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2013 Oct 18

PMID 24131799

Citations 14

Authors

Joost P M Melis

Martijs J Jonker

Jan Vijg

Jan H J Hoeijmakers

Timo M Breit

Harry van Steeg

Affiliations

Soon will be listed here.

Abstract

In the next decades the elderly population will increase dramatically, demanding appropriate solutions in health care and aging research focusing on healthy aging to prevent high burdens and costs in health care. For this, research targeting tissue-specific and individual aging is paramount to make the necessary progression in aging research. In a recently published study we have attempted to make a step interpreting aging data on chronological as well as pathological scale. For this, we sampled five major tissues at regular time intervals during the entire C57BL/6J murine lifespan from a controlled in vivo aging study, measured the whole transcriptome and incorporated temporal as well as physical health aspects into the analyses. In total, we used 18 different age-related pathological parameters and transcriptomic profiles of liver, kidney, spleen, lung and brain and created a database that can now be used for a broad systems biology approach. In our study, we focused on the dynamics of biological processes during chronological aging and the comparison between chronological and pathology-related aging.

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References

Glass D, Vinuela A, Davies M, Ramasamy A, Parts L, Knowles D . Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol. 2013; 14(7):R75. PMC: 4054017. DOI: 10.1186/gb-2013-14-7-r75. View

Ludlow A, Witkowski S, Marshall M, Wang J, Lima L, Guth L . Chronic exercise modifies age-related telomere dynamics in a tissue-specific fashion. J Gerontol A Biol Sci Med Sci. 2012; 67(9):911-26. PMC: 3436090. DOI: 10.1093/gerona/gls002. View

Zhan M, Yamaza H, Sun Y, Sinclair J, Li H, Zou S . Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Res. 2007; 17(8):1236-43. PMC: 1933522. DOI: 10.1101/gr.6216607. View

Melis J, Luijten M, Mullenders L, van Steeg H . The role of XPC: implications in cancer and oxidative DNA damage. Mutat Res. 2011; 728(3):107-17. PMC: 3203325. DOI: 10.1016/j.mrrev.2011.07.001. View

Katic M, Kennedy A, Leykin I, Norris A, McGettrick A, Gesta S . Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell. 2007; 6(6):827-39. PMC: 5715809. DOI: 10.1111/j.1474-9726.2007.00346.x. View

Fu C, Hickey M, Morrison M, McCarter R, Han E . Tissue specific and non-specific changes in gene expression by aging and by early stage CR. Mech Ageing Dev. 2006; 127(12):905-16. PMC: 1764499. DOI: 10.1016/j.mad.2006.09.006. View

Pulliam D, Bhattacharya A, Van Remmen H . Mitochondrial dysfunction in aging and longevity: a causal or protective role?. Antioxid Redox Signal. 2012; 19(12):1373-87. DOI: 10.1089/ars.2012.4950. View

Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C . Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007; 448(7151):375-9. DOI: 10.1038/nature05949. View

Wang J, Clauson C, Robbins P, Niedernhofer L, Wang Y . The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell. 2012; 11(4):714-6. PMC: 3399950. DOI: 10.1111/j.1474-9726.2012.00828.x. View

10.

Suh Y, Vijg J . Maintaining genetic integrity in aging: a zero sum game. Antioxid Redox Signal. 2006; 8(3-4):559-71. DOI: 10.1089/ars.2006.8.559. View

11.

Swindell W . Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics. 2009; 10:585. PMC: 2795771. DOI: 10.1186/1471-2164-10-585. View

12.

Melis J, Speksnijder E, Kuiper R, Salvatori D, Schaap M, Maas S . Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice. Toxicol Appl Pharmacol. 2012; 266(2):289-97. DOI: 10.1016/j.taap.2012.11.004. View

13.

Sepe S, Payan-Gomez C, Milanese C, Hoeijmakers J, Mastroberardino P . Nucleotide excision repair in chronic neurodegenerative diseases. DNA Repair (Amst). 2013; 12(8):568-77. DOI: 10.1016/j.dnarep.2013.04.009. View

14.

Beltrami E, Ruggiero A, Busuttil R, Migliaccio E, Pelicci P, Vijg J . Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene. Aging Cell. 2012; 12(2):177-83. PMC: 4141878. DOI: 10.1111/acel.12036. View

15.

Moreira P, Santos M, Oliveira C . Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal. 2007; 9(10):1621-30. DOI: 10.1089/ars.2007.1703. View

16.

Vijg J, Busuttil R, Bahar R, Dolle M . Aging and genome maintenance. Ann N Y Acad Sci. 2006; 1055:35-47. DOI: 10.1196/annals.1323.007. View

17.

Liu D, Xu Y . p53, oxidative stress, and aging. Antioxid Redox Signal. 2010; 15(6):1669-78. PMC: 3151427. DOI: 10.1089/ars.2010.3644. View

18.

Swindell W . Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging. BMC Genomics. 2007; 8:353. PMC: 2094713. DOI: 10.1186/1471-2164-8-353. View

19.

Jung T, Bader N, Grune T . Lipofuscin: formation, distribution, and metabolic consequences. Ann N Y Acad Sci. 2007; 1119:97-111. DOI: 10.1196/annals.1404.008. View

20.

Labunskyy V, Gladyshev V . Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2012; 19(12):1362-72. PMC: 3791051. DOI: 10.1089/ars.2012.4891. View