New Frontiers in Type III Secretion Biology: the Chlamydia Perspective

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2013 Oct 16

PMID 24126521

Citations 59

Authors

K E Mueller

G V Plano

K A Fields

Affiliations

Soon will be listed here.

Abstract

Members of the order Chlamydiales comprise a group of exquisitely evolved parasites of eukaryotic hosts that extends from single-celled amoeba to mammals. The most notable are human pathogens and include the agent of oculogenital disease Chlamydia trachomatis, the respiratory pathogen C. pneumoniae, and the zoonotic agent C. psittaci. All of these species are obligate intracellular bacteria that develop within parasitophorous vesicles termed inclusions. This demanding lifestyle necessitates orchestrated entry into nonphagocytic cells, creation of a privileged intracellular niche, and subversion of potent host defenses. All chlamydial genomes contain the coding capacity for a nonflagellar type III secretion system, and this mechanism has arisen as an essential contributor to chlamydial virulence. The emergence of tractable approaches to the genetic manipulation of chlamydiae raises the possibility of explosive progress in understanding this important contributor to chlamydial pathogenesis. This minireview considers challenges and recent advances that have revealed how chlamydiae have maintained conserved aspects of T3S while exploiting diversification to yield a system that exerts a fundamental role in the unique biology of Chlamydia species.

Citing Articles

CT584 Is Not a Protective Vaccine Antigen against Respiratory Chlamydial Challenge in Mice.

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The N-terminus of the effector Tarp engages the host Hippo pathway.

Aranjuez G, Patel O, Patel D, Jewett T bioRxiv. 2024; .

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Insights into Chlamydia Development and Host Cells Response.

Yang S, Zeng J, Yu J, Sun R, Tuo Y, Bai H Microorganisms. 2024; 12(7).

PMID: 39065071 PMC: 11279054. DOI: 10.3390/microorganisms12071302.

Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen.

Hoang-Phou S, Pal S, Slepenkin A, Abisoye-Ogunniyun A, Zhang Y, Gilmore S bioRxiv. 2024; .

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Molecular pathogenesis of .

Jury B, Fleming C, Huston W, Luu L Front Cell Infect Microbiol. 2023; 13:1281823.

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