Compartmentalization of the Submembrane Calcium Activity During Calcium Influx and Its Significance in Transmitter Release

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1985 Sep 1

PMID 2412607

Citations 227

Authors

S M Simon

R R Llinas

Affiliations

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Abstract

Quantitative modeling indicates that, in presynaptic terminals, the intracellular calcium concentration profile during inward calcium current is characterized by discrete peaks of calcium immediately adjacent to the calcium channels. This restriction of intracellular calcium concentration suggests a remarkably well specified intracellular architecture such that calcium, as a second messenger, may regulate particular intracellular domains with a great degree of specificity.

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