Nucleotide Sequence of the Visna Lentivirus: Relationship to the AIDS Virus

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 1985 Aug 1

PMID 2410140

Citations 192

Authors

P Sonigo

M Alizon

K Staskus

D Klatzmann

S Cole

O Danos

E Retzel

P Tiollais

A Haase

S Wain-Hobson

Affiliations

Soon will be listed here.

Abstract

We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

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