Transcriptional Regulation by Hypoxia Inducible Factors

Overview

Journal Crit Rev Biochem Mol Biol

Publisher Informa Healthcare

Specialties Biochemistry
Molecular Biology

Date 2013 Oct 9

PMID 24099156

Citations 382

Authors

Veronica L Dengler

Matthew Galbraith

Joaquin M Espinosa

Affiliations

Soon will be listed here.

Abstract

The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.

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