Distinct Recognition Phenotypes Exist for T Cell Clones Specific for Small Peptide Regions of Proteins. Implications for the Mechanisms Underlying Major Histocompatibility Complex-restricted Antigen Recognition and Clonal Deletion Models of Immune...

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1985 Jul 1

PMID 2409209

Citations 20

Authors

N Shastri

A Oki

A Miller

E E Sercarz

Affiliations

Soon will be listed here.

Abstract

Using synthetic peptides as antigens, it was found that T cell clones of a given haplotype specific for 13-16 amino acid peptides could be clearly distinguished by the varied influence of amino acid substitutions on recognition. This was true for different antigenic determinants within peptides 81-96 and 74-86 of hen egg-white lysozyme, recognized in the context of the I-Ab and I-Ak molecules, respectively. Considerable complexity was demonstrated in the induced T cell repertoire specific for apparently single determinants, which implies that diversity of T cell recognition approaches that for B cells. The implications of the degeneracy of T cell recognition are discussed in the context of mechanisms through which Ia molecules restrict recognition and theories of Ir gene defects.

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