Anorexia Nervosa, Obesity and Bone Metabolism

Overview

Journal Pediatr Endocrinol Rev

Specialties Endocrinology
Pediatrics

Date 2013 Oct 2

PMID 24079076

Citations 15

Authors

Madhusmita Misra

Anne Klibanski

Affiliations

Soon will be listed here.

Abstract

Anorexia nervosa and obesity are conditions at the extreme ends of the nutritional spectrum, associated with marked reductions versus increases respectively in body fat content. Both conditions are also associated with an increased risk for fractures. In anorexia nervosa, body composition and hormones secreted or regulated by body fat content are important determinants of low bone density, impaired bone structure and reduced bone strength. In addition, anorexia nervosa is characterized by increases in marrow adiposity and decreases in cold activated brown adipose tissue, both of which are related to low bone density. In obese individuals, greater visceral adiposity is associated with greater marrow fat, lower bone density and impaired bone structure. In this review, we discuss bone metabolism in anorexia nervosa and obesity in relation to adipose tissue distribution and hormones secreted or regulated by body fat content.

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