Microtubule-associated Proteins in Mesial Temporal Lobe Epilepsy with and Without Psychiatric Comorbidities and Their Relation with Granular Cell Layer Dispersion

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Sep 27

PMID 24069608

Citations 11

Authors

Ludmyla Kandratavicius

Mariana Raquel Monteiro

Jaime Eduardo Hallak

Carlos Gilberto Carlotti Jr

Joao Alberto Assirati Jr

Joao Pereira Leite

Affiliations

Soon will be listed here.

Abstract

Background: Despite strong association between epilepsy and psychiatric comorbidities, biological substrates are unknown. We have previously reported decreased mossy fiber sprouting in mesial temporal lobe epilepsy (MTLE) patients with psychosis and increased in those with major depression. Microtubule associated proteins (MAPs) are essentially involved in dendritic and synaptic sprouting.

Methods: MTLE hippocampi of subjects without psychiatric history, MTLE + major depression, and MTLE + interictal psychosis derived from epilepsy surgery and control necropsies were investigated for neuronal density, granular layer dispersion, and MAP2 and tau immunohistochemistry.

Results: Altered MAP2 and tau expression in MTLE and decreased tau expression in MTLE with psychosis were found. Granular layer dispersion correlated inversely with verbal memory scores, and with MAP2 and tau expression in the entorhinal cortex. Patients taking fluoxetine showed increased neuronal density in the granular layer and those taking haloperidol decreased neuronal density in CA3 and subiculum.

Conclusions: Our results indicate relations between MAPs, granular layer dispersion, and memory that have not been previously investigated. Differential MAPs expression in human MTLE hippocampi with and without psychiatric comorbidities suggests that psychopathological states in MTLE rely on differential morphological and possibly neurochemical backgrounds. This clinical study was approved by our institution's Research Ethics Board (HC-FMRP no. 1270/2008) and is registered under the Brazilian National System of Information on Ethics in Human Research (SISNEP) no. 0423.0.004.000-07.

Citing Articles

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Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.

Busch R, Yehia L, Bazeley P, Seyfi M, Blumcke I, Hermann B Epilepsia. 2020; 61(10):2203-2213.

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