Targeting Neurodegeneration to Prevent Post-traumatic Epilepsy

Overview

Journal Neurobiol Dis

Specialty Neurology

Date 2018 Aug 13

PMID 30099094

Citations 16

Authors

Idrish Ali

Juliana C Silva

Shijie Liu

Sandy R Shultz

Patrick Kwan

Nigel C Jones

Terence J OBrien

Affiliations

Soon will be listed here.

Abstract

In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

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References

Lozano D, Gonzales-Portillo G, Acosta S, De la Pena I, Tajiri N, Kaneko Y . Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities. Neuropsychiatr Dis Treat. 2015; 11:97-106. PMC: 4295534. DOI: 10.2147/NDT.S65815. View

Corrigan F, Pham C, Vink R, Blumbergs P, Masters C, Van Den Heuvel C . The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. Brain Res. 2011; 1378:137-43. DOI: 10.1016/j.brainres.2010.12.077. View

Jones N, Nguyen T, Corcoran N, Velakoulis D, Chen T, Grundy R . Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models. Neurobiol Dis. 2011; 45(3):897-901. DOI: 10.1016/j.nbd.2011.12.005. View

McKee A, Stern R, Nowinski C, Stein T, Alvarez V, Daneshvar D . The spectrum of disease in chronic traumatic encephalopathy. Brain. 2012; 136(Pt 1):43-64. PMC: 3624697. DOI: 10.1093/brain/aws307. View

Chen L, Wang Y, Tseng G . Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons. J Neurotrauma. 2010; 27(9):1657-69. DOI: 10.1089/neu.2010.1308. View

Shahim P, Rejdak R, Ksiazek P, Blennow K, Zetterberg H, Mattsson N . Cerebrospinal fluid biomarkers of β-amyloid metabolism and neuronal damage in epileptic seizures. Eur J Neurol. 2013; 21(3):486-91. DOI: 10.1111/ene.12336. View

Seo J, Lee S, Shin J, Hwang Y, Cho H, Yoo S . Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017; 49(5):e333. PMC: 5454448. DOI: 10.1038/emm.2017.56. View

Mehan S, Meena H, Sharma D, Sankhla R . JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J Mol Neurosci. 2010; 43(3):376-90. DOI: 10.1007/s12031-010-9454-6. View

An S, See M, Kim H, Park S, Hwang I, Won M . Accumulation of microtubule-associated proteins in the hippocampal neurons of seizure-sensitive gerbils. Mol Cells. 2003; 15(2):200-7. View

10.

Cheng J, Craft R, Yu G, Ho K, Wang X, Mohan G . Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS One. 2015; 9(12):e115765. PMC: 4281043. DOI: 10.1371/journal.pone.0115765. View

11.

Ali I, Avdic U, Chugh D, Ekdahl C . Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain. Cell Mol Immunol. 2017; 15(4):414-417. PMC: 6052830. DOI: 10.1038/cmi.2017.112. View

12.

Sotiropoulos I, Galas M, Silva J, Skoulakis E, Wegmann S, Maina M . Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathol Commun. 2017; 5(1):91. PMC: 5707803. DOI: 10.1186/s40478-017-0489-6. View

13.

Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W . Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014; 76(3):443-56. PMC: 4338764. DOI: 10.1002/ana.24230. View

14.

Liu X, Ou S, Yin M, Xu T, Wang T, Liu Y . N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5. Discov Med. 2017; 23(127):221-234. View

15.

Fukuda M, Suzuki Y, Ishizaki Y, Kira R, Kikuchi C, Watanabe S . Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats. Seizure. 2008; 18(3):211-4. DOI: 10.1016/j.seizure.2008.10.001. View

16.

Murakami N, Yamaki T, Iwamoto Y, Sakakibara T, Kobori N, Fushiki S . Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. J Neurotrauma. 1998; 15(11):993-1003. DOI: 10.1089/neu.1998.15.993. View

17.

Rehman S, Ahmad A, Yoon G, Khan M, Abid M, Kim M . Inhibition of c-Jun N-Terminal Kinase Protects Against Brain Damage and Improves Learning and Memory After Traumatic Brain Injury in Adult Mice. Cereb Cortex. 2017; 28(8):2854-2872. DOI: 10.1093/cercor/bhx164. View

18.

Decker J, Kruger L, Sydow A, Dennissen F, Siskova Z, Mandelkow E . The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Rep. 2016; 17(4):552-69. PMC: 4818782. DOI: 10.15252/embr.201541439. View

19.

Xu H, Wang Z, Li J, Wu H, Peng Y, Fan L . The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plast. 2017; 2017:5405104. PMC: 5309408. DOI: 10.1155/2017/5405104. View

20.

Matsumoto G, Sakai H . Microtubules inside the plasma membrane of squid giant axons and their possible physiological function. J Membr Biol. 1979; 50(1):1-14. DOI: 10.1007/BF01868784. View