Yield of Contact Investigations in Households of Patients with Drug-resistant Tuberculosis: Systematic Review and Meta-analysis

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2013 Sep 26

PMID 24065336

Citations 72

Authors

N Sarita Shah

Courtney M Yuen

Moonseong Heo

Arielle W Tolman

Mercedes C Becerra

Affiliations

Soon will be listed here.

Abstract

Contact investigations among individuals living with drug-susceptible tuberculosis patients (source cases) have shown a high yield of tuberculosis disease and latent tuberculosis, but the yield of such investigations in households of drug-resistant tuberculosis source cases is unknown. In this systematic review and meta-analysis, we found 25 studies that evaluated a median of 111 (interquartile range, 21-302) household contacts of drug-resistant tuberculosis source cases. The pooled yield was 7.8% (95% CI, 5.6%-10.0%) for active tuberculosis and 47.2% (95% CI, 30.0%-61.4%) for latent tuberculosis, although there was significant statistical heterogeneity (P < .0001). More than 50% of secondary cases with drug susceptibility test results were concordant with those of the source case. Among studies that followed household members, the majority of secondary cases were detected within 1 year of the source case's diagnosis. Household contact investigation around drug-resistant tuberculosis patients is a high-yield intervention for detection of drug-resistant tuberculosis and prevention of ongoing transmission.

Citing Articles

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Daniel W, Tadesse S, Tamirat T, Selamu M BMJ Public Health. 2025; 3(1):e001531.

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The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.

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