» Articles » PMID: 19220360

Fitness Cost of Drug Resistance in Mycobacterium Tuberculosis

Overview
Publisher Elsevier
Date 2009 Feb 18
PMID 19220360
Citations 54
Authors
Affiliations
Soon will be listed here.
Abstract

Multidrug-resistant (MDR)--and extensively drug-resistant (XDR)--forms of tuberculosis are growing public health problems. Mathematical models predict that the future of the MDR and XDR tuberculosis epidemics depends in part on the competitive fitness of drug-resistant strains. Here, recent experimental and molecular epidemiological data that illustrate how heterogeneity among drug-resistant strains of Mycobacterium tuberculosis can influence the relative fitness and transmission of this pathogen are reviewed.

Citing Articles

Development and validation of a nomogram predicting multidrug-resistant tuberculosis risk in East China.

He F, Wang S, Wang H, Ding X, Huang P, Fan X PeerJ. 2025; 13:e19112.

PMID: 40034676 PMC: 11874934. DOI: 10.7717/peerj.19112.


Rifampicin tolerance and growth fitness among isoniazid-resistant clinical isolates from a longitudinal study.

Vijay S, Bao N, Vinh D, Nhat L, Thu D, Quang N Elife. 2024; 13.

PMID: 39250422 PMC: 11383526. DOI: 10.7554/eLife.93243.


Genetic diversity, evolution and drug resistance of lineage 2.

Atavliyeva S, Auganova D, Tarlykov P Front Microbiol. 2024; 15:1384791.

PMID: 38827149 PMC: 11140050. DOI: 10.3389/fmicb.2024.1384791.


Multidrug-resistant tuberculosis.

Dheda K, Mirzayev F, Cirillo D, Udwadia Z, Dooley K, Chang K Nat Rev Dis Primers. 2024; 10(1):22.

PMID: 38523140 DOI: 10.1038/s41572-024-00504-2.


Phenotype versus genotype discordant rifampicin susceptibility testing in tuberculosis: implications for a diagnostic accuracy.

Qadir M, Faryal R, Khan M, Khan S, Zhang S, Li W Microbiol Spectr. 2023; 12(1):e0163123.

PMID: 37982632 PMC: 10783056. DOI: 10.1128/spectrum.01631-23.