Biomarkers for the Management of Pre-eclampsia in Pregnant Women

Overview

Journal Indian J Med Res

Specialty General Medicine

Date 2013 Sep 24

PMID 24056556

Citations 7

Authors

Lakshmi Tanuja Petla

Rosy Chikkala

K S Ratnakar

Vijayalakshmi Kodati

V Sritharan

Affiliations

Soon will be listed here.

Abstract

Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia.

Citing Articles

Neutrophil Gelatinase-Associated Lipocalin and Hypertensive Disorders of Pregnancy: A Cohort Study in Twin Pregnancies.

Springer S, Franz M, Worda K, Gorczyca M, Haslinger P, Worda C J Clin Med. 2022; 11(14).

PMID: 35887927 PMC: 9318711. DOI: 10.3390/jcm11144163.

Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients.

Sanchez B, Gasalla J, Sanchez-Chapado M, Bort A, Diaz-Laviada I J Clin Med. 2021; 10(23).

PMID: 34884175 PMC: 8658290. DOI: 10.3390/jcm10235474.

Neutrophil Gelatinase-associated Lipocalin: As a Predictor of Early Diabetic Nephropathy in Type 2 Diabetes Mellitus.

Kaul A, Behera M, Rai M, Mishra P, Bhaduaria D, Yadav S Indian J Nephrol. 2018; 28(1):53-60.

PMID: 29515302 PMC: 5830810. DOI: 10.4103/ijn.IJN_96_17.

Antigen Analysis of Pre-Eclamptic Plasma Antibodies Using Proteome Chips.

Hsu T, Lin J, Nguyen M, Chung F, Tsai C, Cheng H Mol Cell Proteomics. 2017; 17(8):1457-1469.

PMID: 29284593 PMC: 6072543. DOI: 10.1074/mcp.RA117.000139.

Are the blood groups of women with preeclampsia a risk factor for the development of hypertension postpartum?.

Avci D, Karagoz H, Ozer O, Esmeray K, Bulut K, Aykas F Ther Clin Risk Manag. 2016; 12:617-22.

PMID: 27143904 PMC: 4844302. DOI: 10.2147/TCRM.S100557.

References

Hawkins R . New biomarkers of acute kidney injury and the cardio-renal syndrome. Korean J Lab Med. 2011; 31(2):72-80. PMC: 3116003. DOI: 10.3343/kjlm.2011.31.2.72. View

Grill S, Rusterholz C, Zanetti-Dallenbach R, Tercanli S, Holzgreve W, Hahn S . Potential markers of preeclampsia--a review. Reprod Biol Endocrinol. 2009; 7:70. PMC: 2717076. DOI: 10.1186/1477-7827-7-70. View

Romero R, Nien J, Espinoza J, Todem D, Fu W, Chung H . A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a.... J Matern Fetal Neonatal Med. 2008; 21(1):9-23. PMC: 2587364. DOI: 10.1080/14767050701830480. View

Akolekar R, Syngelaki A, Sarquis R, Zvanca M, Nicolaides K . Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11-13 weeks. Prenat Diagn. 2011; 31(1):66-74. DOI: 10.1002/pd.2660. View

Mishra J, Dent C, Tarabishi R, Mitsnefes M, Ma Q, Kelly C . Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005; 365(9466):1231-8. DOI: 10.1016/S0140-6736(05)74811-X. View

Wagner L . Diagnosis and management of preeclampsia. Am Fam Physician. 2004; 70(12):2317-24. View

Mutter W, Karumanchi S . Molecular mechanisms of preeclampsia. Microvasc Res. 2007; 75(1):1-8. PMC: 2241748. DOI: 10.1016/j.mvr.2007.04.009. View

DAnna R, Baviera G, Giordano D, Russo S, Dugo N, Santamaria A . First trimester serum PAPP-A and NGAL in the prediction of late-onset pre-eclampsia. Prenat Diagn. 2009; 29(11):1066-8. DOI: 10.1002/pd.2339. View

Kalkunte S, Nevers T, Norris W, Sharma S . Vascular IL-10: a protective role in preeclampsia. J Reprod Immunol. 2011; 88(2):165-9. PMC: 3621108. DOI: 10.1016/j.jri.2011.01.009. View

10.

DAnna R, Baviera G, Giordano D, Todarello G, Russo S, Recupero S . Neutrophil gelatinase-associated lipocalin serum evaluation through normal pregnancy and in pregnancies complicated by preeclampsia. Acta Obstet Gynecol Scand. 2009; 89(2):275-8. DOI: 10.3109/00016340903443676. View

11.

Levine R, Maynard S, Qian C, Lim K, England L, Yu K . Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004; 350(7):672-83. DOI: 10.1056/NEJMoa031884. View

12.

Law L, Sahota D, Chan L, Chen M, Lau T, Leung T . Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. J Matern Fetal Neonatal Med. 2011; 24(6):808-11. DOI: 10.3109/14767058.2010.531309. View

13.

Huppertz B, Kawaguchi R . First trimester serum markers to predict preeclampsia. Wien Med Wochenschr. 2012; 162(9-10):191-5. DOI: 10.1007/s10354-012-0072-5. View

14.

Agarwal I, Karumanchi S . Preeclampsia and the Anti-Angiogenic State. Pregnancy Hypertens. 2011; 1(1):17-21. PMC: 3087187. DOI: 10.1016/j.preghy.2010.10.007. View

15.

Vaisbuch E, Romero R, Mazaki-Tovi S, Erez O, Kwon Kim S, Chaiworapongsa T . Retinol binding protein 4--a novel association with early-onset preeclampsia. J Perinat Med. 2009; 38(2):129-39. PMC: 2962937. DOI: 10.1515/jpm.2009.140. View

16.

DAnna R, Baviera G, Giordano D, Todarello G, Corrado F, Buemi M . Second trimester neutrophil gelatinase-associated lipocalin as a potential prediagnostic marker of preeclampsia. Acta Obstet Gynecol Scand. 2008; 87(12):1370-3. DOI: 10.1080/00016340802464463. View

17.

Molvarec A, Kalabay L, Derzsy Z, Szarka A, Halmos A, Stenczer B . Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. Hypertens Res. 2009; 32(8):665-9. DOI: 10.1038/hr.2009.79. View

18.

Szarka A, Rigo Jr J, Lazar L, Beko G, Molvarec A . Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol. 2010; 11:59. PMC: 3014878. DOI: 10.1186/1471-2172-11-59. View

19.

Nicolaides K, Bindra R, Turan O, Chefetz I, Sammar M, Meiri H . A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound. Ultrasound Obstet Gynecol. 2005; 27(1):13-17. DOI: 10.1002/uog.2686. View

20.

Desai J, Torry R, Caudle M, Torry D . Signal transduction and biological function of placenta growth factor in primary human trophoblast. Biol Reprod. 1999; 60(4):887-92. DOI: 10.1095/biolreprod60.4.887. View