New Biomarkers of Acute Kidney Injury and the Cardio-renal Syndrome

Overview

Journal Korean J Lab Med

Specialty Pathology

Date 2011 Apr 9

PMID 21474979

Citations 16

Authors

Robert Hawkins

Affiliations

Soon will be listed here.

Abstract

Changes in renal function are one of the most common manifestations of severe illness. There is a clinical need to intervene early with proven treatments in patients with potentially deleterious changes in renal function. Unfortunately progress has been hindered by poor definitions of renal dysfunction and a lack of early biomarkers of renal injury. In recent years, the definitional problem has been addressed with the establishment of a new well-defined diagnostic entity, acute kidney injury (AKI), which encompasses the wide spectrum of kidney dysfunction, together with clearer definition and sub-classification of the cardio-renal syndromes. From the laboratory have emerged new biomarkers which allow early detection of AKI, including neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C. This review describes the new concepts of AKI and the cardio-renal syndromes as well as novel biomarkers which allow early detection of AKI. Panels of AKI biomarker tests are likely to revolutionize the diagnosis and management of critically ill patients in the coming years. Earlier diagnosis and intervention should significantly reduce the morbidity and mortality associated with acute kidney damage.

Citing Articles

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Cardiorenal syndrome in thalassemia patients.

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Evaluation of serum neutrophil gelatinase-associated lipocalin as a novel biomarker of cardiorenal syndrome in dogs.

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NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus.

Papadopoulou-Marketou N, Margeli A, Papassotiriou I, Chrousos G, Kanaka-Gantenbein C, Wahlberg J J Diabetes Res. 2017; 2017:7526919.

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Evaluation of serum neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in critically ill patients.

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