Chiral Silanediols in Anion-binding Catalysis

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2013 Sep 17

PMID 24039105

Citations 34

Authors

Andrew G Schafer

Joshua M Wieting

Thomas J Fisher

Anita E Mattson

Affiliations

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Abstract

A perfect pair: Silanediols are effective catalysts for the addition of silyl ketene acetals to N-acylisoquinolinium ions. Importantly, this is the first example of a silanediol plausibly participating in anion-binding catalysis, a relatively new direction in the field of hydrogen-bond-donor catalysis. The chiral, enantiopure C2 -symmetric silanediol 1 catalyzes enantioselective transformations.

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