Structural Evaluation and Analyses of Tumor Differentiation Factor

Overview

Journal Protein J

Publisher Springer

Specialty Biochemistry

Date 2013 Sep 17

PMID 24037223

Citations 3

Authors

Urmi Roy

Alisa G Woods

Izabela Sokolowska

Costel C Darie

Affiliations

Soon will be listed here.

Abstract

Tumor differentiation factor (TDF) is a protein produced by the pituitary and secreted into the blood stream. The mechanism of its action has still not been elucidated, although the associated protein receptor was identified. Furthermore, the TDF protein does not have any homology with other known proteins, and the crystal structure of TDF also is not available at this time. To gain some insight into the structure of this rather underexplored protein, we have performed a molecular dynamics simulation of a model TDF structure. The structural stability of this protein is evaluated as a function of time. The time dependent structural changes of four cysteine residues present in this structure also are explored.

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