Robust Suppression of Env-SHIV Viremia in Macaca Nemestrina by 3-drug ART is Independent of Timing of Initiation During Chronic Infection

Overview

Journal J Med Primatol

Publisher Wiley

Date 2013 Sep 13

PMID 24025078

Citations 14

Authors

Christopher W Peterson

Patrick Younan

Patricia S Polacino

Nicholas J Maurice

Hannah W Miller

Martin Prlic

Keith R Jerome

Ann E Woolfrey

Shiu-Lok Hu

Hans-Peter Kiem

Affiliations

Soon will be listed here.

Abstract

Background: Nonhuman primates (NHPs) are an important model organism for studies of HIV pathogenesis and preclinical evaluation of anti-HIV therapies. The successful translation of NHP-derived data to clinically relevant anti-HIV studies will require better understanding of the viral strains and NHP species used and their responses to existing antiretroviral therapies (ART).

Methods: Five pigtailed macaques (Macaca nemestrina) were productively infected with the SIV/HIV chimeric virus SHIV-1157 ipd3N4 following intravenous challenge. After 8 or 27 weeks, ART (PMPA, FTC, raltegravir) was initiated. Viral load, T-cell counts, and production of SHIV-specific antibodies were monitored throughout the course of infection and ART.

Results: ART led to a rapid and sustained decrease in plasma viral load. Suppression of plasma viremia by ART was independent of the timing of initiation during chronic infection.

Conclusions: We present a new NHP model of HIV infection on antiretroviral therapy, which should prove applicable to multiple clinically relevant anti-HIV approaches.

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